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The percentage of −2 pro–prostate-specific antigen and the prostate health inde...
Garrido, Manuel Matos; Marta, José C.; Bernardino, Rui M.; Guerra, João; Fernandes, Francisco; Pereira, Maria H.; Ribeiro, Ruy; Holdenrieder, StefanContext.—: There is a need to avoid the overdiagnosis of prostate cancer (PCa) and to find more specific biomarkers. Objective.—: To evaluate the clinical utility of [-2]pro-prostate-specific antigen ([-2]proPSA) derivatives in detecting clinically significant PCa (csPCa) and to compare it with prostate-specific antigen (PSA) and with the percentage of free PSA (%fPSA). Design.—: Two hundred thirty-seven men (P...
Are proinflammatory cytokines relevant for the diagnosis of prostate cancer?
Garrido, Manuel Matos; Ribeiro, Ruy; Krüger, Kimberly; Pinheiro, Luís C.; Guimarães, João T.; Holdenrieder, StefanBackground/aim: Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml. Patients and methods: Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1β, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regard...
The prostate health index (PHI) density : are there advantages over PHI or over...
Garrido, Manuel Matos; Ribeiro, Ruy; Pinheiro, Luís C.; Holdenrieder, Stefan; Guimarães, João T.Background and aims: Overdiagnosis of prostate cancer (PCa) should be minimized. We wanted to evaluate the diagnostic performance of the prostate health index density (PHID) and compare it with that of the prostate health index (PHI) alone and of the prostate-specific antigen density (PSAD). Materials and methods: 232 men scheduled for a prostate biopsy (prostate-specific antigen level: 2-10 µg/L), were enrolle...