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Companion animals-An overlooked and misdiagnosed reservoir of carbapenem resist...

da Silva, Joana Moreira; Menezes, Juliana; Marques, Cátia Filipa Saraiva; Pomba, C.

Research Areas: Infectious Diseases ; Pharmacology & Pharmacy; ABSTRACT - The dissemination of antimicrobial-resistance is a major global threat affecting both human and animal health. Carbapenems are human use β-lactams of last resort; thus. the dissemination of carbapenemase-producing (CP) bacteria creates severe limitations for the treatment of multidrugresistant bacteria in hospitalized patients. Even thoug...


Human and companion animal proteus mirabilis sharing

Marques, Cátia Filipa Saraiva; Belas, Adriana; Menezes, Juliana; da Silva, Joana Moreira; Cavaco-Silva, Patrícia; Trigueiro, Graça; Gama, Luis

Research Areas: Microbiology; Proteus mirabilis is an important pathogen that is associated with urinary tract infections. This study aims to determine the colonization and sharing of P. mirabilis between healthy companion animals and humans that are living together and to evaluate the clonal relatedness of the fecal and clinical stains. Eighteen households (24 humans, 18 dogs, 8 cats) with at least one human–a...


Clonal relatedness of Proteus mirabilis strains causing urinary tract infection...

Marques, Cátia Filipa Saraiva; Belas, Adriana; Aboim, Catarina; Trigueiro, Graça; Cavaco-Silva, Patrícia; Gama, Luis; Pomba, C.

Research Areas: Microbiology. Veterinary Sciences; ABSTRACT - Proteus mirabilis is a major cause of urinary tract infection (UTI) in humans and companion animals. This study aimed to evaluate the antimicrobial resistance, virulence and clonal relatedness of P. mirabilis isolated from dogs, cats and humans with UTI. P. mirabilis isolated from companion animals (N = 107) and humans (N = 76) with UTI were compared...


Evidence of sharing of Klebsiella pneumoniae strains between healthy companion ...

Marques, Cátia Filipa Saraiva; Belas, Adriana; Aboim, Catarina; Cavaco-Silva, Patrícia; Trigueiro, Graça; Gama, Luis; Pomba, C.

Research Areas: Microbiology; This study aimed to characterize the fecal colonization and sharing of Klebsiella pneumoniae strains between companion animals and humans living in close contact. Fecal samples were collected from 50 healthy participants (24 humans, 18 dogs, and 8 cats) belonging to 18 households. Samples were plated onto MacConkey agar (MCK) plates with and without cefotaxime or meropenem suppleme...


Meglumine antimoniate and miltefosine combined with allopurinol sustain pro-inf...

Santos, Marcos André Ferreira; Alexandre-Pires, Graça; Pereira, Maria A.; Marques, Cátia Filipa Saraiva; Gomes, Joana; Correia, Jorge Manuel de Jesus

Research Areas: Veterinary Sciences; Canine leishmaniosis (CanL) caused by Leishmania infantum is a zoonotic disease of global concern. Antileishmanial drug therapies commonly used to treat sick dogs improve their clinical condition, although when discontinued relapses can occur. Thus, the current study aims to evaluate the effect of CanL treatments in peripheral blood, lymph node, and bone marrow cytokine prof...


Frequência do antigénio eritrocitário DEA 1.1 em canídeos e dos antigénios erit...

Marques, Cátia Filipa Saraiva

Dissertação de Mestrado Integrado em Medicina Veterinária; O sistema sanguíneo AB dos felídeos, caracterizado por Auer e Bell, é considerado como o clinicamente mais relevante. O antigénio eritrocitário canino (DEA) 1.1 é o mais antigénico e consequentemente responsável pelas reacções transfusionais adversas mais severas. Este estudo teve como objectivo determinar a frequência dos antigénios eritrocitários do s...


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