14 documents found, page 1 of 2
Paracoccidioides HSP90 can be found in the cell surface and is a target for ant...
Moura, Ágata Nogueira D’Áurea; Oliveira, Diane Sthefany Lima de; Paredes, Verenice; Rocha, Letícia Barboza; Oliveira, Fabiana Freire Mende deParacoccidioidomycosis (PCM) is one of the most frequent systemic mycoses in Latin America. It affects mainly male rural workers in impoverished regions, and the therapy can last up to two years or use drugs that are very toxic. Given the need for novel safe and effective approaches to treat PCM, we have been developing monoclonal antibodies (mAbs) that could be used not only to block specific fungal targets, b...
Faster cryptococcus melanization increases virulence in experimental and human ...
Sousa, Herdson Renney de; Oliveira Júnior, Getúlio Pereira de; Frazão, Stefânia de Oliveira; Gorgonha, Kaio César de Melo; Rosa, Camila PereiraCryptococcus spp. are human pathogens that cause 181,000 deaths per year. In this work, we systematically investigated the virulence attributes of Cryptococcus spp. clinical isolates and correlated them with patient data to better understand cryptococcosis. We collected 66 C. neoformans and 19 C. gattii clinical isolates and analyzed multiple virulence phenotypes and host–pathogen interaction outcomes. C. neofo...
Neuroprotective effects on microglia and insights into the structure–activity r...
Plácido, Alexandra; Amaral, Constança Pais Do; Teixeira, Cátia; Nogueira, Ariane; Brango‐Vanegas, José; Alves Barbosa, Eder; C. Moreira, DanielTryptophyllins constitute a heterogeneous group of peptides that are one of the first classes of peptides identified from amphibian's skin secretions. Here, we report the structural characterization and antioxidant properties of a novel tryptophyllin-like peptide, named PpT-2, isolated from the Iberian green frog Pelophylax perezi. The skin secretion of P. perezi was obtained by electrical stimulation and fract...
Neuroprotective effects on microglia and insights into the structure–activity r...
Plácido, Alexandra; Amaral, Constança do Pais do; Teixeira, Cátia; Nogueira, Ariane; Brango-Vanegas, José; Barbosa, Eder Alves; Moreira, Daniel C.Tryptophyllins constitute a heterogeneous group of peptides that are one of the first classes of peptides identified from amphibian’s skin secretions. Here, we report the structural characterization and antioxidant properties of a novel tryptophyllin-like peptide, named PpT-2, isolated from the Iberian green frog Pelophylax perezi. The skin secretion of P. perezi was obtained by electrical stimulation and fract...
Acetylated cashew gum and fucan for incorporation of lycopene rich extract from...
Andrades, Eryka Oliveira de; Costa, João Marcos Antônio Rodrigues da; Neto, Francisco Edmar Moreira de Lima; Araujo, Alyne Rodrigues deIndustrial application of lycopene is limited due to its chemical instability and low bioavailability. This study proposes the development of fucan-coated acetylated cashew gum nanoparticles (NFGa) and acetylated cashew gum nanoparticles (NGa) for incorporation of the lycopene-rich extract from red guava (LEG). Size, polydispersity, zeta potential, nanoparticles concentration, encapsulation efficiency, transmis...
Cryptococcal virulence in humans : learning from translational studies with cli...
Sousa, Herdson Renney de; Frazão, Stefânia de Oliveira; Oliveira Júnior, Getúlio Pereira de; Albuquerque, Patrícia; Nicola, André MoraesCryptococcosis, an invasive mycosis caused by Cryptococcus spp, kills between 20% and 70% of the patients who develop it. There are no vaccines for prevention, and treatment is based on a limited number of antifungals. Studying fungal virulence and how the host responds to infection could lead to new therapies, improving outcomes for patients. The biggest challenge, however, is that experimental cryptococcosis ...
Transcriptional remodeling patterns in murine dendritic cells infected with Par...
Silva, Calliandra Maria de Souza; Hurtado, Fabián Andrés; Tavares, Aldo Henrique Fonseca Pacheco; Oliveira Júnior, Getúlio Pereira de; Raiol, TaináMost people infected with the fungus Paracoccidioides spp. do not get sick, but approximately 5% develop paracoccidioidomycosis. Understanding how host immunity determinants influence disease development could lead to novel preventative or therapeutic strategies; hence, we used two mouse strains that are resistant (A/J) or susceptible (B10.A) to P. brasiliensis to study how dendritic cells (DCs) respond to the ...
Paracoccidioides HSP90 can be found in the cell surface and is a target for ant...
Moura, Ágata Nogueira D’Áurea; Oliveira, Diane Sthefany Lima de; Paredes, Verenice; Rocha, Leticia Barboza; Oliveira, Fabiana Freire Mendes deParacoccidioidomycosis (PCM) is one of the most frequent systemic mycoses in Latin America. It affects mainly male rural workers in impoverished regions, and the therapy can last up to two years or use drugs that are very toxic. Given the need for novel safe and effective approaches to treat PCM, we have been developing monoclonal antibodies (mAbs) that could be used not only to block specific fungal targets, b...
A hidden battle in the dirt: Soil amoebae interactions with Paracoccidioides spp
Albuquerque, Patrícia; Nicola, André Moraes; Magnabosco, Diogo Almeida Gomes; da Silveira Derengowski, Lorena; Crisóstomo, Luana SoaresMade available in DSpace on 2020-12-12T01:42:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Paracoccidioides spp. are thermodimorphic fungi that cause a neglected tropical disease (paracoccidioidomycosis) that is endemic to Latin America. These fungi inhabit the soil, where they live as saprophytes with no need for a mammalian host to complete their life cycle. Despite this, they developed sop...
The antioxidant peptide salamandrin-i: First bioactive peptide identified from ...
Plácido, Alexandra; Bueno, João; Barbosa, Eder A.; Moreira, Daniel C.; Dias, Jhones Do Nascimento; Cabral, Wanessa Felix; Albuquerque, PatríciaMade available in DSpace on 2020-12-12T02:01:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01; Universidade Estadual Paulista; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação para a Ciência e a Tecnologia; Amphibian skin is a multifunctional organ that plays key roles in defense, breathing, and wat...