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Design, Synthesis and Antifungal Activity of New Schiff Bases Bearing 2-Aminoth...
Luna,Isadora S.; Neves,Wendell W.; Lima-Neto,Reginaldo G. de; Albuquerque,Amanda P. B.; Pitta,Maíra G. R.; Rêgo,Moacyr J. B. M.; Neves,Rejane P.Seventeen Schiff bases bearing 2-aminothiophene derivatives were designed and synthesized using molecular simplification. The resulting compounds (4a-4q) were evaluated for their in vitro antifungal activity against dermatophytes. Prediction of their druglikeness and pharmacokinetic properties, establishment of their structure-activity relationships (SAR), and cytotoxic evaluation of the most active compounds w...
Date: 2021
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Origin: Oasisbr