7 documents found, page 1 of 1
Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenerge...
Correia, Sónia C.; Machado, Nuno J.; Alves, Marco G; Oliveira, Pedro F.; Moreira, Paula I.The lack of effective disease-modifying therapeutics to tackle Alzheimer's disease (AD) is unsettling considering the actual prevalence of this devastating neurodegenerative disorder worldwide. Intermittent hypoxic conditioning (IHC) is a powerful non-pharmacological procedure known to enhance brain resilience. In this context, the aim of the present study was to investigate the potential long-term protective i...
Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflamm...
Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana R.; Pochmann, Daniela; Machado, Nuno J.; Tomé, Ângelo R.; Agostinho, PaulaDepressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P2X7 receptors (P2X7R) and adenosine A2A receptors (A2AR) antagonists attenuate behavioral modifications upon exposure to repeated stress. Since it is unknown if these two purinergic modulation systems work independently, we now investigated a putative interplay betwee...
Liraglutide Protects Against Brain Amyloid-β1-42 Accumulation in Female Mice wi...
Duarte, Ana I.; Candeias, Emanuel; Alves, Inês; Mena, Débora; Silva, Daniela F.; Machado, Nuno J.; Campos, Elisa J.; Santos, Maria S.Alzheimer's disease (AD) is the most common form of dementia worldwide, being characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the amyloid beta (Aβ) peptide and hyperphosphorylated tau (p-tau), respectively) and memory loss. Aging, type 2 diabetes (T2D) and female sex (especially after menopause) are risk factors for AD, but their crosslinking mechanisms remain unclear. Mo...
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Tr...
Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia; Augusto, Elisabete de Oliveira; Silva, Henrique B.; Machado, Nuno J.; Gonçalves, NélioNeurodegeneration is a process transversal to neuropsychiatric diseases and the understanding of its mechanisms should allow devising strategies to prevent this irreversible step in brain diseases. Neurodegeneration caused by seizures is a critical step in the aggravation of temporal lobe epilepsy, but its mechanisms remain undetermined. Convulsions trigger an elevation of extracellular adenosine and upregulate...
Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control D...
Leffa, Douglas T; Pandolfo, Pablo; Gonçalves, Nélio; Machado, Nuno J.; de Souza, Carolina M; Real, Joana I.; Silva, Antonio C.; Silva, Henrique B.Adenosine A2A receptors (A2ARs) were recently described to control synaptic plasticity and network activity in the prefrontal cortex (PFC). We now probed the role of these PFC A2AR by evaluating the behavioral performance (locomotor activity, anxiety-related behavior, cost-benefit decision making and working memory) of rats upon downregulation of A2AR selectively in the prelimbic medial PFC (PLmPFC) via viral s...
Caffeine reverts memory but not mood impairment in a depression-prone mouse str...
Machado, Nuno J.; Simoes, Ana Patricia; Silva, Henrique B.; Ardais, Ana Paula; Kaster, Manuella P.; Garcao, Pedro; Rodrigues, Diana I.Caffeine prophylactically prevents mood and memory impairments through adenosine A(2A) receptor (A(2A)R) antagonism. A(2A)R antagonists also therapeutically revert mood and memory impairments, but it is not known if caffeine is also therapeutically or only prophylactically effective. Since depression is accompanied by mood and memory alterations, we now explored if chronic (4 weeks) caffeine consumption (0.3 g/...
Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical ...
Rial, Daniel; Castro, Adalberto A.; Machado, Nuno J.; Garção, Pedro; Gonçalves, Francisco Q.; Silva, Henrique B.; Tomé, Ângelo R.; Köfalvi, AttilaThere is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the appearance of the characteristic motor symptoms. Neuropsychiatric, sensorial and cognitive deficits are recognized as early non-motor manifestations of PD, and are not attenuated by the current anti-parkinsonian therapy. Although loss-of-function mutations in the...