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Travel-associated international spread of Oropouche virus beyond the Amazon

Iani, Felipe Campos de Melo; Pereira, Felicidade Mota; Oliveira, Elaine Cristina de; Rodrigues, Janete Taynã Nascimento; Machado, Mariza Hoffmann

Oropouche virus (OROV), first detected in Trinidad and Tobago in 1955, was historically confined to the Brazilian Amazon Basin. However, since late 2022, an increasing number of OROV cases have been reported across various regions of Brazil as well as in urban centers in Bolivia, Ecuador, Guyana, Colombia, Cuba, Panama, and Peru. In collaboration with Central Public Health Laboratories across Brazil, we integra...


Establishing a dengue genomic monitoring in Cuba: uncovering virus dynamics to ...

Pérez, Melissa; Álvarez, Mayling; Perez, Lissette; Benitez, Ana Julia; Serrano, Silvia; Adelino, Talita Emile Ribeiro; Fonseca, Vagner; Resik, Sonia

Background: A major dengue outbreak was reported by the Cuban Ministry of Health in 2022, highlighting the need for strong surveillance, with high pediatric cases showing warning signs. Using phylogenetic and epidemiologic approaches, we provide evidence toward a better understanding of dengue's recent transmission history. Methods: This study details the implementation of the genomic surveillance system for De...


Insights into SARS-CoV-2 surveillance among prison populations in Mato Grosso d...

Silva, Liliane Ferreira da; Alcantara, Luiz Carlos Junior; Fonseca, Vagner; Frias, Diego; Zardin, Marina Castilhos Souza Umaki

This study examines the epidemiological and genomic characteristics, along with the transmission dynamics, of SARS-CoV-2 within prison units I and II in Campo Grande, Mato Grosso do Sul, Brazil. Conducted between May and October 2022, it reveals how the virus spreads in the confined settings of prisons, emphasizing the roles of overcrowded cells, frequent transfers, and limited healthcare access. The research i...


Integrated analyses of the transmission history of SARS-CoV-2 and its associati...

Cella, Eleonora; Fonseca, Vagner; Branda, Francesco; Tosta, Stephane; Moreno, Keldenn; Schuab, Gabriel; Ali, Sobur; Slavov, Svetoslav Nanev

Background: Italy was significantly affected by the COVID-19 pandemic, experiencing multiple waves of infection following the sequential emergence of new variants. Understanding the transmission patterns and evolution of SARS-CoV-2 is vital for future preparedness. Methods: We conducted an analysis of viral genome sequences, integrating epidemiological and phylodynamic approaches, to characterize how SARS-CoV-2...


Genomics-based timely detection of dengue virus type I genotypes I and V in Uru...

Morel, Noelia; Giovanetti, Marta; Fonseca, Vagner; Burgueño, Analía; Lima, Mauricio; Castro, Emerson; Guimarães, Natália R.; Iani, Felipe C. M.

This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integ...


Correction to “Exploring the urban arbovirus landscape in Rio de Janeiro, Brazi...

Schuab, Gabriel; Tosta, Stephane; Moreno, Keldenn; Fonseca, Vagner; Santos, Luciane Amorim; Slavov, Svetoslav Nanev; Kashima, Simone; Ciccozzi, Massimo

The authors wish to correct the data sharing statement, acknowledgments and include a citation for the published work and apologise for any inconvenience the error may have caused.


North–south pathways, emerging variants, and high climate suitability character...

Miguel, Isaac; Feliz, Edwin P.; Agramonte, Robinson; Martinez, Pedro V.; Vergara, Carlos; Imbert, Yvonne; Cruz, Lucia De la; Castro, Nurys de

Background: Dengue fever remains a significant public health challenge in tropical and subtropical regions, with its transmission dynamics being influenced by both environmental factors and human mobility. The Dominican Republic, a biodiversity hotspot in the Caribbean, has experienced recurrent dengue outbreaks, yet detailed understanding of the virus's transmission pathways and the impact of climatic factors ...


Dengue virus transmission in Italy: historical trends up to 2023 and a data rep...

Branda, Francesco; Nakase, Taishi; Maruotti, Antonello; Scarpa, Fabio; Ciccozzi, Alessandra; Romano, Chiara; Peletto, Simone

Dengue virus circulation is on the rise globally, with increased epidemic activity in previously unaffected countries, including within Europe. In 2023, global dengue activity peaked, and Italy reported the highest number of dengue cases and local chains of transmission to date. By curating several sources of information, we introduce a novel data repository focused on dengue reporting in Italy. We integrate da...


Genomic and eco-epidemiological investigations in Uruguay reveal local Chikungu...

Burgueño, Analía; Giovanetti, Marta; Fonseca, Vagner; Morel, Noelia; Lima, Mauricio; Castro, Emerson; Guimarães, Natália R.; Iani, Felipe C. M.

Uruguay experienced its first Chikungunya virus outbreak in 2023, resulting in a significant burden to its healthcare system. We conducted analysis based on real-time genomic surveillance (30 novel whole genomes) to offer timely insights into recent local transmission dynamics and eco-epidemiological factors behind its emergence and spread in the country.


Exploring the urban arbovirus landscape in Rio de Janeiro, Brazil: transmission...

Schuab, Gabriel; Tosta, Stephane; Moreno, Keldenn; Fonseca, Vagner; Santos, Luciane Amorim; Slavov, Svetoslav Nanev; Kashima, Simone; Ciccozzi, Massimo

Background: This study focuses on urban arboviruses, specifically dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV), which pose a significant public health challenge in Rio de Janeiro state, Southeast Brazil. In our research, we highlight critical findings on the transmission dynamics of these arboviruses in Rio de Janeiro, identifying distinct patterns of disease spread. Methods: By combining genomic data wi...


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