2 documents found, page 1 of 1
Standardization of organoid culture for evaluation of melanogenesis induced by ...
Olivatti,Thainá Oliveira Felicio; Alcantara,Giovana Piteri; Lemos,Ana Cláudia Cavalcante Espósito; Silva,Márcia Guimarães da; Miot,Hélio AmanteAbstract Background: Organoid cultures are primary cultures that maintain architectural characteristics and the relationships between cells, as well as the extracellular matrix. They are alternatives for pathophysiological or therapeutic investigation rather than animal and in vitro tests. Objective: Development of a cutaneous organoid culture model, aiming at the study of radiation-induced melanogenesis. Metho...
Evaluation of ex vivo melanogenic response to UVB, UVA, and visible light in fa...
Alcantara,Giovana Piteri; Esposito,Ana Cláudia Cavalcante; Olivatti,Thainá Oliveira Felicio; Yoshida,Melissa Mari; Miot,Hélio AmanteAbstract Background: The independent role of solar radiation in the differential melanogenesis between melasma and adjacent skin is unknown. Objectives: To assess the melanogenic responses of skin with facial melasma and of the adjacent skin to UVB, UVA, and visible light, in an ex vivo model. Methods: This was a quasi-experimental study involving 22 patients with melasma. Facial melasma and adjacent skin sampl...