6 documents found, page 1 of 1
Reappraising the need for a control CT in mild head injury patients on anticoag...
Marques, Renata Sofia Ferreira; Antunes, Cristiano; Machado, Maria João; Ramos, Rui; Duarte, Nubélio; Oliveira, Leandro; Alegria, Carlos; Sousa, NunoBackground Head injury is a frequent reason for admission to the emergency department. In parallel, there is a growing use of anticoagulants in an increasingly aging population, which renders this particular group of trauma patients more frequent. In several countries, including Portugal, a 24-h surveillance period followed by repetition of head computed tomography (CT) is the standard procedure for these patie...
Pharmacological versus microvascular decompression approaches for the treatment...
Lemos, Laurinda; Alegria, Carlos; Oliveira, Joana; Machado, Ana; Oliveira, Pedro; Almeida, ArmandoIn idiopathic trigeminal neuralgia (TN) the neuroimaging evaluation is usually normal, but in some cases a vascular compression of trigeminal nerve root is present. Although the latter condition may be referred to surgery, drug therapy is usually the first approach to control pain. This study compared the clinical outcome and direct costs of (1) a traditional treatment (carbamazepine [CBZ] in monotherapy [CBZ p...
Impact of EGFR genetic variants on glioma risk and patient outcome
Costa, Bruno Marques; Pereira, Marta Viana; Fernandes, Ricardo; Costa, S.; Linhares, Paulo; Vaz, Rui; Pinheiro, Céline; Lima, Jorge; Soares, PaulaBACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide polymorphisms in the essential promoter region, -216G/T and -191C/A, and a polymorphic (CA)(n) microsatellite sequence in intron 1. We aimed to elucidate the...
Sublabial versus columellar incision in trans-septal transsphenoidal approach f...
Guimarães, Joana; Santos, Joana; Miranda, Daniel; Moreira, Filipa Carvalho; Marçal, Nuno; Pereira, Gabriel; Marques, Olinda; Almeida, RuiObjectives: To compare the sublabial incision with the columellar incision in trans-septal transsphenoidal approach of microscopic pituitary surgery, concerning per-operative complications and observed sequelae.Study Design: Retrospective study.Material and methods: Revision of the clinical records of 50 patients submitted to transsphenoidal microscopic surgery to resection of pituitary adenoma, in Braga Hospit...
Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...
Costa, Bruno Marques; Caeiro, Cláudia; Guimarães, Inês; Martinho, Olga; Jaraquemada, Teresa; Augusto, Isabel; Castro, Lígia; Osório, LígiaGlioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...
Spinal subdural haematoma.
Ribeiro, Manuel; Cerqueira, João; Fernandes, João; Alegria, Carlos; Rocha, JaimeSpinal subdural haematoma is a rare pathology and may cause severe neurological deficit. In this paper a case of acute spinal subdural haematoma of multifactorial etiology--traumatic versus iatrogenic--is presented, in which the clinical evaluation, Computerized Tomography and Magnetic Resonance were of utmost importance as far as the early diagnosis is concerned, allowing therefore decompressive surgery to avo...