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Utilização off-label de omalizumab bem sucedida numa criança com urticária crón...

Gonçalves, Tânia; Alen Coutinho, Iolanda; Pita, Joana Sofia; Leiria Pinto, Paula

Omalizumab está aprovado como terapêutica de terceira linha em doentes a partir dos 12 anos de idade com urticária crónica espontânea refratária a anti-histamínicos. É apresentado o caso de um rapaz de oito anos de idade com história de lesões cutâneas maculopapulares migratórias, artralgias e hiperemia conjuntival. Os resultados analíticos não demonstraram alterações relevantes e a biópsia cutânea fo...


Fever of Unknown Origin in a Portuguese Tertiary Hospital: A Cohort Study

Ferreira, Mafalda; Alen Coutinho, Iolanda; Lavrador, Mariana; Duarte, Odete; Esperto, Helder; de Carvalho, Armando

Introduction: Fever of unknown origin (FUO) remains a major diagnostic challenge, despite advances in the medical field. It can be caused by a broad spectrum of diseases with very different prognostic outcomes. Constant re-evaluation of clinical data is essential considering the dynamic changes in disease patterns. We aim to understand which clinical approach is most commonly used and recognize our local epidem...


Angioedema: Diagnostic and Therapeutic Approach in the Emergency Department

Alen Coutinho, Iolanda; Luís Marques, Maria; Carneiro-Leão, Leonor; Santos, Natacha; Castro Neves, Ana; Gaspar, Ângela; Spínola Santos, Amélia

N/a.; N/a.

Date: 2022   |   Origin: Acta Médica Portuguesa

A Case of Acute Interstitial Nephritis After Two Doses of the BNT162b2 SARS-CoV...

Mira, Filipe; Costa Carvalho, Jóni; de Almeida, Patrícia Amaral; Pimenta, Ana Carolina; Alen Coutinho, Iolanda; Figueiredo, Carolina; Rodrigues, Luís

The development of vaccines to prevent COVID-19 breakouts came with highly positive results but some unexpected side effects. Rare side effects have been seen with the BNT162b2 SARS-CoV 2 vaccine. Case Presentation: We present the case of a 45-year-old female patient who developed an acute kidney injury needing urgent hemodialysis one week after the second administration of the BNT162b2 SARS-CoV 2 vaccine. She ...


Refractory chronic urticaria in adults: clinical characterization and predictor...

Alen Coutinho, Iolanda; Regateiro, Frederico Soares; Fernandes, Rosa Anita; Pita, Joana Sofia; Gomes, Raquel; Coelho, Constança; Todo-Bom, Ana

Background: Chronic urticaria (CU) is defined as recurrent urticaria lasting for more than 6 weeks. Objectives: We aimed to characterize the phenotypes of patients with CU refractory to standard dose anti-H1 antihistamine treatment and search for clinical predictors of poor disease control. Methods: Retrospective collection of data regarding clinical characteristics, comorbidities, treatment, and disease contro...


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