4 documents found, page 1 of 1
A proline derivative-enriched methanol fraction from Sideroxylon obtusifolium l...
Souza, Tamiris F. G.; Pierdoná, Taiana M.; Macedo, Fernanda Soares; Aquino, Pedro E. A.; Rangel, Gisele F. P.; Duarte, Rebeca S.; Silva, Lorena Mara A.It was previously demonstrated that the methanol fraction of Sideroxylon obtusifolium (MFSOL) promoted anti-inflammatory and healing activity in excisional wounds. Thus, the present work investigated the healing effects of MFSOL on human keratinocyte cells (HaCaT) and experimental burn model injuries. HaCaT cells were used to study MFSOL’s effect on cell migration and proliferation rates. Female Swiss mice were...
Amifostine reduces inflammation and protects against 5-fluorouracil-induced ora...
Barbosa, Sabrina Carneiro Melo; Pereira, Venúcia B.M.; Wong, Deysi V.T.; Santana, Ana P.M.; Lucetti, Larisse T.; Carvalho, Lucas L.Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) andradiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable.Amifostine is a cytoprotective agent with a described anti-inflammatory potential. It is clinically used to reduce radiotherapy andchemotherapy-associated xerostomia. Th...
Side-effects of irinotecan (CPT-11), the clinically used drug for colon cancer ...
Alencar, Nylane Maria Nunes de; Bitencourt, Flávio da Silveira; Figueiredo, Ingrid Samantha Tavares de; Luz, Patrícia BastosIntestinal mucositis (IM) is the critical side effect of irinotecan (CPT-11), which is the front-line drug used for the treatment of colorectal cancer. This study aimed to evaluate the effectiveness of latex proteins (LP) from Calotropis procera to prevent IM and diarrhea in animals. Swiss mice were treated daily with saline or LP (1, 5, or 50 mg/kg, i.v.) 24 h prior to CTP-11 (75 mg/kg/4 days, i.p) and for add...
Low-dose combination of alendronate and atorvastatin reduces ligature-induced a...
Dutra, Paula Goes Pinheiro; Melo, Iracema Matos; Silva, Luana Maria Castelo Melo; Benevides, Norma Maria Barros; Alencar, Nylane Maria Nunes deMaterial and Methods: Periodontitis was induced by ligature in 78 Wistar rats. Groups of six rats prophylactically received 0.9% saline (SAL), ALD (0.01 or 0.25 mg/kg subcutaneously) or ATV (0.3 or 27 mg/kg by gavage). Then, groups of six rats received the combination of ALD+ATV (0.25 mg/kg + 27 mg/kg, 0.01 mg/ kg + 0.3 mg/kg, 0.25 mg/kg + 0.3 mg/kg or 0.01 mg/kg + 27 mg/kg) prophylactically. An extra group of ...