7 documents found, page 1 of 1
Conversational agents for health and well-being across the life course: protoco...
Guerreiro, Mara Pereira; Angelini, Leonardo; Henriques, Helga Rafael; Kamali, Mira El; Baixinho, Cristina; Balsa, João; Félix, Isa britoBackground: Conversational agents, which we defined as computer programs that are designed to simulate two-way human conversation by using language and are potentially supplemented with nonlanguage modalities, offer promising avenues for health interventions for different populations across the life course. There is a lack of open-access and user-friendly resources for identifying research trends and gaps and p...
Aplicación de las tecnologías de la industria 4.0 al diseño y fabricación de pr...
Alexandre, Bruno; Salguero, Jorge; Peralta-Alvarez, Maria-Estela; Aguayo-Gonzalez, Francisco; Ares, EnriqueConsidering as a starting point the principles that characterize the artisanal and industrial production systems, this article explore the mechanisms to promote interdisciplinary relationship between industrial designers, industrial manufacturers and artisans; the main objective is to enhance the knowledge for the development and consolidation of the craft activity. We propose a methodology which industrial fac...
Proteomics of Red Blood Cells from Patients with Obstructive Sleep Apnea
Feliciano, Amelia; Bozanic, Vesna; Torres, Vukosava Milic; Matthiesen, Rune; Carvalho, Ana S.; Almeida, Andreia; Alexandre, Bruno; Vaz, FátimaObstructive sleep apnea (OSA) is a common public health concern causing metabolic and cardiovascular consequences. Although OSA is a systemic disease, the molecular mechanisms and specific genes/proteins associated with such processes remain poorly defined.To identify dysregulated proteins that could be useful as candidate biomarkers of diagnosis/prognosis of OSA., is the aim of this study
Profiling the erythrocyte membrane proteome isolated from patients diagnosed wi...
Alexandre, Bruno; Charro, Nuno; Blonder, Yosip; Lopes, Carlos; Almeida, Antonio Bugalho; Veenstra, Timothy; Penque, Deborah; Azevedo, Pilar; Chan, K.C.Structural and metabolic alterations in erythrocytes play an important role in the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD). Whether these dysfunctions are related to the modulation of erythrocyte membrane proteins in patients diagnosed with COPD remains to be determined. Herein, a comparative proteomic profiling of the erythrocyte membrane fraction isolated from peripheral blood of smoke...
Chronic Obstructive Pulmonary Disease and Proteomics: A Match for Success?
Alexandre, Bruno; Penque, DeborahChronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation that is not fully reversible even under bronchodilators effect, caused by a mixture of small airway disease and parenchymal destruction. COPD is a major cause of morbidity and mortality in adults, and it is now the fourth leading death cause in the world. Cigarette smoking is the main risk factor for COPD but not all smo...
Proteomics in Detection and Monitoring Chronic Lung Diseases: The Human Nasal E...
Simões, Tânia; Charro, Nuno; Alexandre, Bruno; Penque, DeborahAsthma and chronic obstructive pulmonary disease (COPD) are major causes of mortality and morbidity worldwide. The current state-of-art diagnosis and management schemes are suboptimal for both diseases as the incidence of asthma has risen by 250% over the last two decades and COPD is estimated to become the third leading cause of death worldwide within the next decade. Additionally, these diseases represent a v...
Tobacco smoke occupational exposure: biomarkers of biological damage
Simões, Tânia; Torres, Vukosava; Pacheco, Solange; Louro, Henriqueta; Silva, Maria Joao; Charro, Nuno; Alexandre, Bruno; Vaz, Fatima; Penque, DeborahHigh concentration of toxic substances emanated from tobacco smoke in entertainment places such as restaurants, bars and nightclubs may compromise indoor air quality (IAQ) generating environments of likelihood health risk. Their employees, particularly those exposed to second-hand smoke, are at increased risk for developing chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthm...