4 documents found, page 1 of 1
Oxaliplatin toxicity presenting as a liver nodule - case report
Alexandrino, H; Oliveira, D; Cipriano, MA; Ferreira, L; Tralhão, JG; Castro e Sousa, FBACKGROUND: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Her...
Locally advanced adenocarcinoma of the rectum presenting with necrotising fasci...
Ferreira, L; Alexandrino, H; Soares Leite, J; Castro e Sousa, FColorectal cancer is a common malignant neoplasm and its treatment usually involves surgery associated, in some cases, depending on the staging, with chemoradiotherapy. Necrotising fasciitis of the perineum is a highly lethal infection of the perineum, perirectal tissues and genitals, requiring emergency surgical debridement, broad-spectrum antibiotics and control of sepsis. We present the case of a 59-year-old...
Rupture of splenic angiosarcoma: a rare cause of spontaneous haemoperitoneum
Alexandrino, H; Tralhão, JG; Castro e Sousa, F; Julião, MJPrimary splenic angiosarcoma, a very rare mesenchymal tumour of endothelial cell origin, comprises 2.6% of all cases of angiosarcoma and 10% of all primitive splenic tumours. Clinical presentation is usually unspecific, with abdominal pain and anaemia. Rupture is a rare complication and should prompt emergency splenectomy. Prognosis is usually poor because of liver, lung or bone metastases. We describe the case...
Peritoneal and hepatic hydatid disease causing major bile duct destruction
Vieira, V; Alexandrino, H; Furtado, E; Martinho, FEchinococcosis is endemic in Mediterranean regions and is found primarily in the liver. Biliary fistula is a common complication, but major biliary duct involvement is very rare, and occurs in 0.47% of patients with hepatic hydatid disease. Cyst rupture causing secondary peritoneal hydatidosis is a rare but serious complication. We report the case of a 27-year-old man with multiple peritoneal and hepatic hydati...