2 documents found, page 1 of 1
Acute MDPV Binge Paradigm on Mice Emotional Behavior and Glial Signature
Campeão, Mafalda; Fernandes, Luciana; Pita, Inês R.; Lemos, Cristina; Ali, Syed F.; Carvalho, Félix; Rodrigues-Santos, Paulo; Ribeiro, Carlos A. Fontes3,4-Methylenedioxypyrovalerone (MDPV), a widely available synthetic cathinone, is a popular substitute for classical controlled drugs of abuse, such as methamphetamine (METH). Although MDPV poses public health risks, its neuropharmacological profile remains poorly explored. This study aimed to provide evidence on that direction. Accordingly, C57BL/6J mice were exposed to a binge MDPV or METH regimen (four intra...
Single or multiple injections of methamphetamine increased dopamine turnover bu...
Pereira, Frederico Costa; Lourenço, Elita Santos; Borges, Fernanda; Morgadinho, Teresa; Ribeiro, Carlos Fontes; Macedo, Tice Reis; Ali, Syed F.Methamphetamine (METH), leading to striatal dopamine (DA) nerve terminal toxicity in mammals, is also thought to induce apoptosis of striatal neurons in rodents. We investigated the acute effects induced by multiple injections of METH (4 × 5 mg/kg, i.p.) at 2-h intervals or a single injection of METH (20 mg/kg, i.p.) on terminal dopaminergic toxicity markers, including DA levels, DA turnover, and tyrosine hydro...