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Valproyl-dephosphocoa

Silva, MFB; Ijlst, L; Allers, P; Jakobs, C; Duran, M; de Almeida, IT; Wanders, RJA

The mitochondrial metabolism of valproic acid (VPA) was investigated in vitro to elucidate its beta-oxidation pathway since the characterization of VPA intermediates in the acyl-CoA thioester form, and not just in their free acid form, has not been fully

Date: 2004   |   Origin: Repositório da Universidade de Lisboa
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Synthesis and intramitochondrial levels of valproyl-coenzyme A metabolites

Silva, MFB; Ruiter, JPN; IJlst, L; Allers, P; ten Brink, HJ; Jakobs, C; Duran, M; de Almedia, IT; Wander, RJA

A number of valproate adverse reactions are due to its interference with several metabolic pathways, including that of fatty acid oxidation. In order to resolve which mitochondrial enzymes of fatty acid oxidation are inhibited by which VPA intermediates w

Date: 2001   |   Origin: Repositório da Universidade de Lisboa
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