5 documents found, page 1 of 1
Overweight, Obesity, And Cardiovascular Disease In Heterozygous Familial Hyperc...
Elshorbagy, Amany; Vallejo-Vaz, Antonio J.; Barkas, Fotios; Lyons, Alexander R.M.; Stevens, Christophe A.T.; Dharmayat, Kanika I.; Catapano, Alberico L.Background and aims: Overweight and obesity are modifiable risk factors for atherosclerotic cardiovascular disease (ASCVD) in the general population, but their prevalence in individuals with heterozygous familial hypercholesterolaemia (HeFH) and whether they confer additional risk of ASCVD independent of LDL cholesterol (LDL-C) remains unclear. Methods: Cross-sectional analysis was conducted in 35 540 patients ...
Global variation in lipoprotein/a levels among patients with coronary heart dis...
Barkas, Fotios; Brandts, Julia; De Bacquer, Dirk; Jennings, Catriona; De Backer, Guy G.; Kotseva, Kornelia; Ryden, Lars; Lip, Gregory Y. H.Background Lipoprotein(a) [Lp(a)] is a common risk factor for atherosclerotic cardiovascular disease, potentially more atherogenic per particle than low-density lipoprotein. An estimated 1.5 billion individuals globally have elevated levels ≥125 nmol/L, considered as a risk-enhancing threshold. Although Lp(a) levels vary by ethnicity, ongoing trials of novel therapies in predominantly secondary prevention patie...
Frequency of residual combined dyslipidemia and hypertriglyceridemia in patient...
Santos, Raul D.; Ray, Kausik K.; De Bacquer, Dirk; Jennings, Catriona; Kotseva, Kornelia; Rydén, Lars; Lip, Gregory Y. H.; Erlund, Iris; Ganly, SandraBackground and aims: Hypertriglyceridemia (HTG) is independently associated with risk of atherosclerotic events, even when LDL-cholesterol levels appear controlled. This INTERASPIRE study determined the frequency of HTG and residual combined dyslipidemia and their related factors in patients with coronary heart disease (CHD) from 13 countries across six World Health Organization (WHO) regions. Methods: Particip...
Variation in secondary prevention of coronary heart disease: the INTERASPIRE study
McEvoy, John William; Jennings, Catriona; Kotseva, Kornelia; De Bacquer, Dirk; De Backer, Guy; Erlund, Iris; Vihervaara, Terhi; Lip, Gregory Y HBackground and aims: INTERASPIRE is an international study of coronary heart disease (CHD) patients, designed to measure if guideline standards for secondary prevention and cardiac rehabilitation are being achieved in a timely manner. Methods: Between 2020 and 2023, adults hospitalized in the preceding 6-24 months with incident or recurrent CHD were sampled in 14 countries from all 6 World Health Organization r...
Obesity and cardiovascular disease: mechanistic insights and management strateg...
Lopez-Jimenez, Francisco; Almahmeed, Wael; Bays, Harold; Cuevas, Ada; Di Angelantonio, Emanuele; le Roux, Carel W.; Sattar, Naveed; Sun, Marie ChanThe ongoing obesity epidemic represents a global public health crisis that contributes to poor health outcomes, reduced quality of life, and >2.8 million deaths each year. Obesity is relapsing, progressive, and heterogeneous. It is considered a chronic disease by the World Obesity Federation (WOF) and a chronic condition by the World Heart Federation (WHF). People living with overweight/obesity are at greater r...