Fundacao para a Ciencia e a Tecnologia (FCT) (SFRH/BD/68527/2010); Wellcome Trust ISSF grant (097831/Z/11/Z); FCT (SFRH/BD/68532/2010; SFRH/BPD/75295/2010); Research on the obligate intracellular bacterium Chlamydia trachomatis demands culture in cell-lines, but the adaptive process behind the in vivo to in vitro transition is not understood. We assessed the genomic and transcriptomic dynamics underlying C.Trac...