15 documents found, page 1 of 2
Model amphipathic peptide coupled with tacrine to improve its antiproliferative...
Silva, S; Alves, C; Duarte, D; Costa, A; Sarmento, B; Almeida, AJ; Gomes, P; Vale, NDrug repurposing and drug combination are two strategies that have been widely used to overcome the traditional development of new anticancer drugs. Several FDA-approved drugs for other indications have been tested and have demonstrated beneficial anticancer effects. In this connection, our research group recently reported that Tacrine, used to treat Alzheimer’s Disease, inhibits the growth of breast cancer MCF...
The rs5743836 polymorphism in TLR9 confers a population-based increased risk of...
Carvalho, A; Cunha, C; Almeida, AJ; Osório, NS; Saraiva, M; Teixeira-Coelho, M; Pedreiro, S; Torrado, E; Domingues, N; Gomes-Alves, AG; Marques, ANon-Hodgkin lymphoma (NHL) has been associated with immunological defects, chronic inflammatory and autoimmune conditions. Given the link between immune dysfunction and NHL, genetic variants in toll-like receptors (TLRs) have been regarded as potential predictive factors of susceptibility to NHL. Adequate anti-tumoral responses are known to depend on TLR9 function, such that the use of its synthetic ligand is b...
Antibiotics processed by supercritical fluids
Pinheiro, L; Bettencourt, A; Matos, A; Bettencourt, K; Matos, HA; Rodrigues, MA; Padrela, L; Monteiro, J; Almeida, AJ; Castro, M; Duarte, A
Efficiency of water removal from water/ethanol mixtures using supercritical car...
Rodrigues, MA; Li, J; Almeida, AJ; Matos, HA; de Azevedo, EGTechniques involving supercritical carbon dioxide have been successfully used for the formation of drug particles with controlled size distributions. However, these processes show some limitations, particularly in processing aqueous solutions. A diagram walking algorithm based on available experimental data was developed to evaluate the effect of ethanol on the efficiency of water removal processes under differ...
Effect of additives on the biological function of recombinant human phenylalani...
Nascimento, C; Ramos, L; Almeida, AJ; Tavares de Almeida, I; Leandro, P
Stability of spironolactone in an extemporaneously prepared aqueous suspension
Salgado, AC; Rosa, ML; Duarte, A; Almeida, AJ
Microcomposites theophylline/hydrogenated palm oil from a PGSS process for cont...
Rodrigues, M; Peirico, N; Matos, H; de Azevedo, EG; Lobato, MR; Almeida, AJNew controlled-release carriers of theophylline prepared with hydrogenated palm oil (HPO) were obtained by Particles from gas saturated solutions (PGSS) at different working pressures. Pressure had no significant effect on the mean diameter of the particles (of about 3.0 mum). However, spherical morphology with a regular surface was preferentially obtained at higher expansion pressures. HPLC analysis revealed a...
Pulmonary delivered lipid nanoparticles as potential drug carriers for cancer t...
Almeida, AJ
Protein release from alginate microparticles
Florindo, HF; Almeida, AJ
Cross-linked alginate-gelatine beads
Almeida, PF; Almeida, AJThis work is focused on the development of a new particulate drug delivery system using a sodium alginate matrix containing pindolol as a model drug molecule for intestinal drug prolonged release. Calcium alginate beads are known to be unable to control the release of most insoluble drugs. Pindolol-loaded alginate-gelatine beads have been developed using a solvent-free technique that involves a cross-linking re...