9 documents found, page 1 of 1
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers...
Sumaria, Nital; Fiala, Gina; Inácio, Daniel; Curado Avelar, Marta Maria; Cachucho, Ana; Pinheiro, Rúben; Wiesheu, Robert; Kimura, ShunsukeThe contribution of γδ T cells to immune responses is associated with rapid secretion of interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T cells that express CD8αβ heterodimers and expand in preclinical models of infection and cancer. Optimal CD8αβ+ γδ T cell development is directed by low T cell receptor signaling and through provision of interleukin (IL)-4 and IL-7. Th...
Petrology of the tephrite-phonolite suite and cognate xenoliths of the Fortalez...
Macciotta, Giampaolo; Almeida, Afonso; Barbieri, Mario; Beccaluva, Luigi; Brotzu, Piero; Coltorti, Massimo; Conte, Aida; Garbarino, CarloThe alkaline district of Fortaleza (Cearä, Brazil) consists of a number of phonotephritic plugs, domes, and dykes cropping out in the Precambrian basement, aged around 30 Ma.Chemically and petrographically the rocks range in composition from tephrites and phonolitic tephrites to peralkaline phonolites. At one locality (Caruru), olivine clinopyroxenite, essexite, and nepheline syenite xenoliths of cognate origin...
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells ty...
Gomes, André; Farias, Guilherme B.; Dias Silva, Manuel; Laia, Joel; Trombetta, Amelia Chiara; Godinho-Santos, Ana; Rosmaninho, Pedro; Santos, Diana F.Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of ci...
Acute HIV-1 and SARS-CoV-2 infections Share Slan+ Monocyte Depletion - evidence...
Farias, Guilherme B.; Badura, Robert; Conceição, Carolina M.; Gomes, André; Godinho-Santos, Ana; Laia, Joel; Rosmaninho, Pedro; Santos, DianaMonocytes are key modulators in acute viral infections, determining both inflammation and development of specific B- and T-cell responses. Recently, these cells were shown to be associated to different SARS-CoV-2 infection outcome. However, their role in acute HIV-1 infection remains unclear. We had the opportunity to evaluate the mononuclear cell compartment in an early hyper-acute HIV-1 patient in comparison ...
Severe COVID-19 recovery is associated with timely acquisition of a myeloid cel...
Trombetta, Amelia Chiara; Farias, Guilherme B.; Gomes, André; Godinho-Santos, Ana; Rosmaninho, Pedro; Conceição, Carolina M.; Laia, JoelAfter more than one year since the COVID-19 outbreak, patients with severe disease still constitute the bottleneck of the pandemic management. Aberrant inflammatory responses, ranging from cytokine storm to immune-suppression, were described in COVID-19 and no treatment was demonstrated to change the prognosis significantly. Therefore, there is an urgent need for understanding the underlying pathogenic mechanis...
Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia...
Silva, Ana; Almeida, Afonso; Cachucho, Ana; Neto, João Luís; Demeyer, Sofie; Ramos De Matos, Mafalda; Hogan, Thea; Li, Yunlei; Meijerink, JulesTight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL). Although a subset of patients with T-ALL display high IL7R messenger RNA levels and cases with IL7R gains have been reported, the impact of IL-7Rα overexpression, rather than mutational activation, during leukemogenesis remains uncl...
Interleukin-7 receptor α mutational activation can initiate precursor B-cell ac...
Almeida, Afonso; Neto, João Luís; Cachucho, Ana; Euzébio, Mayara; Meng, Xiangyu; Kim, Rathana; Fernandes, Marta; Raposo, Beatriz; Oliveira, Mariana L.Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, establishes a pre-leukemic stage in which B-cell precursors display self-renewal a...
Adaptação dos ruminantes aos climas quentes
Pereira, Alfredo; Titto, Evaldo; Almeida, AfonsoO livro Adaptação dos Ruminantes aos Climas Quentes proporciona uma visão holística acerca das respostas adaptativas dos ruminantes domésticos face aos desafios impostos pela permanência em climas quentes. As relações entre o animal e o ambiente térmico são desenvolvidas evidenciando os mecanismos de permuta de calor e as eventuais consequências na instabilidade da homeotermia. São salientadas as repercussões d...
The neurotrophic factor receptor RET drives haematopoietic stem cell survival a...
Fonseca-Pereira, Diogo; Arroz-Madeira, Sílvia; Rodrigues-Campos, Mariana; Barbosa, Ines A. M.; Domingues, Rita G.; Bento, Teresa; Almeida, AfonsoHaematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self renewing and expanding upon physiological demand. However, the mechanisms that regulate haematopoietic stem cell homeostasis and function remain largely unknown. Here we show that the neurotrophic factor receptor RET (...