3 documents found, page 1 of 1
Immune-monitoring of myelodysplastic neoplasms: recommendations from the i4MDS ...
i4MDS consortium; Tentori, Cristina A.; Zhao, Lin P.; Tinterri, Benedetta; Strange, Kathryn E.; Zoldan, Katharina; Dimopoulos, KonstantinosAdvancements in comprehending myelodysplastic neoplasms (MDS) have unfolded significantly in recent years, elucidating a myriad of cellular and molecular underpinnings integral to disease progression. While molecular inclusions into prognostic models have substantively advanced risk stratification, recent revelations have emphasized the pivotal role of immune dysregulation within the bone marrow milieu during M...
Flow cytometry and targeted immune transcriptomics identify distinct profiles i...
Alves, Raquel; McArdle, Stephanie E B; Vadakekolathu, Jayakumar; Gonçalves, Ana Cristina; Tavares, Paulo; Pereira, Amélia; Almeida, Antonio M.Background: Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive cells [including regulatory T-cells (Treg), myeloid-derived suppressor cells (MDSC)] and express factors such as PD-L1. Molecularly targeted therapies, such as imatinib, have off-target effects...
Flow cytometry and targeted immune transcriptomics identify distinct profiles i...
Alves, Raquel; McArdle, Stephanie E. B.; Vadakekolathu, Jayakumar; Gonçalves, Ana Cristina; Freitas-Tavares, Paulo; Pereira, Amélia; Almeida, Antonio M.BACKGROUND: Tumor cells have evolved complex strategies to escape immune surveillance, a process which involves NK cells and T lymphocytes, and various immunological factors. Indeed, tumor cells recruit immunosuppressive cells [including regulatory T-cells (Treg), myeloid-derived suppressor cells (MDSC)] and express factors such as PD-L1. Molecularly targeted therapies, such as imatinib, have off-target effects...