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Inflammation enhances the risks of stroke and death in chronic chagas disease p...
Guedes, Paulo Marcos da Matta; Andrade, Cléber Mesquita de; Nunes, Daniela Ferreira; Pereira, Nathalie de Sena; Queiroga, Tamyres Bernadete DantasIschemic strokes have been implicated as a cause of death in Chagas disease patients. Inflammation has been recognized as a key component in all ischemic processes, including the intravascular events triggered by vessel interruption, brain damage and repair. In this study, we evaluated the association between inflammatory markers and the death risk (DR) and stroke risk (SR) of patients with different clinical f...
Increased type 1 chemokine expression in experimental Chagas disease correlates...
Guedes, Paulo Marcos da Matta; Veloso, Vanja Maria; Silva, André Talvani Pedrosa da; Diniz, Lívia de Figueiredo; Caldas, Ivo SantanaChemokines and chemokine receptors interaction have presented important role in leukocyte migration to specific immune reaction sites. Recently, it has been reported that chemokine receptors CXC (CXCR3) and CC (CCR5) were preferentially expressed on Th1 cells while CCR3 and CCR4 were preferentially expressed on Th2 cells. This study evaluated the mRNA expression of type 1 and type 2 chemokine and chemokine rece...
Naturally Leishmania infantum-infected dogs display an overall impairment of ch...
Nascimento, Manuela Sales Lima; Albuquerque, Talyta D. R.; Matta, Maria Adelaide do Valle; Caldas, Ivo Santana; Diniz, Lívia de FigueiredoDogs are the primary reservoir for Leishmania parasites. The immune response induced by Leishmania infantum infection in these animals has not been completely elucidated, and few studies have investigated the relationship between the expression levels of chemokines and chemokine receptors and the clinical status of dogs with canine visceral leishmaniasis (CVL). The aim of this study was to correlate the clinica...
Development of chronic cardiomyopathy in canine Chagas disease correlates with ...
Guedes, Paulo Marcos da Matta; Veloso, Vanja Maria; Afonso, Luís Carlos Crocco; Caliari, Marcelo Vidigal; Carneiro, Cláudia MartinsWhen infected with Trypanosoma cruzi, Beagle dogs develop symptoms similar to those of Chagas disease in human beings, and could be an important experimental model for a better understanding of the immunopathogenic mechanisms involved in chronic chagasic infection. This study evaluates IL-10, IFN-g and TNF-a production in the sera, culture supernatant, heart and cervical lymph nodes and their correlation with c...