9 documents found, page 1 of 1

Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blo...

Made available in DSpace on 2022-04-29T08:46:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-23; Multiple organ dysfunction is the most severe outcome of sepsis progression and is highly correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical players in the development of organ failure during sepsis. Therefore, interventions targeting NET release would likely...

Fungal extracellular vesicles are involved in intraspecies intracellular commun...

Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.; ...

Decyl Gallate as a Possible Inhibitor of N-Glycosylation Process in Paracoccidi...

Made available in DSpace on 2020-12-10T19:39:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Programa de Doutorado Sanduiche no Exterior (PDSE); Programa de Apoio ao Desenvolvimento Cientifico da...

Redesigning N-glycosylation sites in a GH3 β-xylosidase improves the enzymatic ...

Made available in DSpace on 2020-12-12T02:23:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-14; Background: β-Xylosidases are glycoside hydrolases (GHs) that cleave xylooligosaccharides and/or xylobiose into shorter oligosaccharides and xylose. Aspergillus nidulans is an established genetic model and good source of carbohydrate-active enzymes (CAZymes). Most fungal enzymes are N-glycosylated, whic...

Extracellular vesicles from the dermatophyte trichophyton interdigitale modulat...

Analyses of the three 1-Cys Peroxiredoxins from Aspergillus fumigatus reveal th...

Made available in DSpace on 2018-11-26T17:54:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-17; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Standing among the front defense strategies against pathogens, host phagocytic cells release various oxidants. Therefore, pathogens have to cope with stressful conditions ...

Paracoccin distribution supports its role in Paracoccidioides brasiliensis grow...

Paracoccidioides brasiliensis yeast was reported to express paracoccin, a GlcNAc-binding protein that displays N-acetyl-β-d-glucosaminidase (NAGase) activity. Highly specific anti-paracoccin antibodies have been previously used to examine the localization of paracoccin in yeast and inhibit its growth in vitro. In the present study, anti-paracoccin antibodies were used to characterize, by scanning confocal micro...

Impact of paracoccin gene silencing on Paracoccidioides brasiliensis Virulence

Among the endemic deep mycoses in Latin America, paracoccidioidomycosis (PCM), caused by thermodimorphic fungi of the Paracoccidioides genus, is a major cause of morbidity. Disease development and its manifestations are associated with both host and fungal factors. Concerning the latter, several recent studies have employed the methodology of gene modulation in P. brasiliensis using antisense RNA (AsRNA) and Ag...

Extracellular vesicles from paracoccidioides brasiliensis induced M1 polarizati...