35 documents found, page 1 of 4

Social innovation and local sustainable development: a literature review

NS1 protein as a novel anti-influenza target: Map-and-mutate antiviral rational...

Influenza NS1 is a promising anti-influenza target, considering its conserved and druggable structure, and key function in influenza replication and pathogenesis. Notwithstanding, target identification and validation, strengthened by experimental data, are lacking. Here, we further explored our previously designed structure-based antiviral rationale directed to highly conserved druggable NS1 regions across a br...

Optimization of A(H1N1)pdm09 vaccine seed viruses: The source of PB1 and HA vRN...

Vaccination prevents and reduces the severity of influenza virus infections. Continuous evolution of influenza hemagglutinin (HA) and neuraminidase (NA) supports the virus to evade pre-existing immunity, which demands vaccines to be reformulated every year. Incorporation of polymerase basic protein 1 (PB1) viral RNA (vRNA) of the same origin of HA and NA vRNA has been observed in previous pandemic viruses and o...

Adaptive evolution of PB1 from influenza A(H1N1)pdm09 virus towards an enhanced...

PB1 influenza virus retain traces of interspecies transmission and adaptation. Previous phylogenetic analyses highlighted mutations L298I, R386K and I517V in PB1 to have putatively ameliorated the A(H1N1)pdm09 adaptation to the human host. This study aimed to evaluate the reversal of these mutations and infer the role of these residues in the virus overall fitness and adaptation. We generate PB1-mutated viruses...

To lose a child of pediatric age: a qualitative study of parental bereavement s...

Aims: The loss of a child of pediatric age is one of the most painful experiences the human being can endure and parental bereavement is an intense and dynamic process that needs monitoring and support. Thus, we aim to identify the needs to be met in the support provided by health professionals and the Centro Hospitalar Universitário de São João (CHUSJ) to parents that experienced the loss of a child of pediatr...

Tyrosine kinase inhibitors are promising therapeutic tools for cats with HER2-p...

ABSTRACT - Feline mammary carcinoma (FMC) is a common neoplasia in cat, being HER2-positive the most prevalent subtype. In woman’s breast cancer, tyrosine kinase inhibitors (TKi) are used as a therapeutic option, by blocking the phosphorylation of the HER2 tyrosine kinase domain. Moreover, clinical trials demonstrated that TKi produce synergistic antiproliferative effects in combination with mTOR inhibitors, ov...

Histone deacetylase inhibitors and microtubule inhibitors induce apoptosis in f...

Simple Summary: Feline mammary tumors (FMT) are very common in cats, associated with very aggressive behavior and a short life expectancy. Surgery is the most used treatment but tumor recurrence is common. Currently, available therapies are insufficient, therefore, new molecular targets are needed to develop more efficient therapeutics. Histone deacetylases inhibitors (HDACis) have been developed to target tumo...

Indirect tensile behaviour of fibre reinforced alkali-activated composites

There are currently still some sustainability-related issues that need to be tackled within the construction sector. Namely, cement production is accountable for nearby 5% of the worldwide total CO2-eq release. Therefore, environmentally viable and economically sustainable solutions need to be pursued in order to mitigate the use of Portland cement. The incorporation of industrial waste in concrete compositions...

Fraude e plágio na Universidade: a urgência de uma cultura de integridade no En...

Uma cultura de integridade para o ensino superior