44 documents found, page 1 of 5

Metformin reverses infertility in a mouse model of endometriosis: unveiling dis...

" Research question: Does metformin reverse endometriosis-associated infertility? Design: Endometriosis was induced by transplanting uterus fragments from B6CBAF1 mice into recipients of the same strain. The mice were divided into groups: endometriosis (End, n = 24), sham-operated (Sham, n = 12), endometriosis with metformin (0.5mg/ml) orally administered for 3 months (EndMet, n = 21) and sham-operated metformi...

Interstitial Cells of Cajal and Enteric Nervous System in Gastrointestinal and ...

The enteric nervous system (ENS) is organized into two plexuses-submucosal and myenteric-which regulate smooth muscle contraction, secretion, and blood flow along the gastrointestinal tract under the influence of the rest of the autonomic nervous system (ANS). Interstitial cells of Cajal (ICCs) are mainly located in the submucosa between the two muscle layers and at the intramuscular level. They communicate wit...

The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models

<jats:p>The different definitions of chronic pelvic/visceral pain used by international societies have changed over the years. These differences have a great impact on the way researchers study chronic pelvic/visceral pain. Recently, the role of systemic changes, including the role of the central nervous system, in the perpetuation and chronification of pelvic/visceral pain has gained weight. Consequently, rese...

Addressing the role of cellular senescence in female fertility

Redox imbalance in age-related ovarian dysfunction and perspectives for its pre...

The age at which women have their first child is increasing. This change represents a major health problem to society because advanced maternal age is related with a decay in fertility and an increase in the incidence of a variety of pregnancy complications and offspring health issues. The ovary stands as the main contributor for female reproductive ageing because of the progressive age-related decrease in foll...

(In)Fertility and Oxidative Stress: New Insights into Novel Redox Mechanisms Co...

Apocynin Dietary Supplementation Delays Mouse Ovarian Ageing

Advanced maternal age is associated with higher infertility rates, pregnancy-associated complications, and progeny health issues. The ovary is considered the main responsible for these consequences due to a continuous decay in follicle number and oocyte quality. Intracellular imbalance between oxidant molecules and antioxidant mechanisms, in favour of the former, results in oxidative stress (OS) that is believe...

Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate fo...

Aging is accompanied by the accumulation of oxidized proteins. To remove them, cells employ the proteasomal and autophagy-lysosomal systems; however, if the clearance rate is inferior to its formation, protein aggregates form as a hallmark of proteostasis loss. In cells, during stress conditions, actin aggregates accumulate leading to impaired proliferation and reduced proteasomal activity, as observed in cellu...

Mobile solutions in depression: Enhancing communication with patients using an ...

Mobile solutions, namely the ones based on the Short Message Service (SMS), can play an important role in enhancing communication with patients with depression, between consultations, allowing the delivery of supportive messages or reminders. This paper presents an overview on this topic and describes a 4-stage study aiming to better understand the mHealth scenario in depression, specifically regarding the use ...

Energy restriction, exercise and atorvastatin treatment improve endothelial dys...

Background: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet ...