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Comparative Effectiveness of COVID-19 Vaccines in Preventing Infections and Dis...

Kislaya, Irina; Casaca, Pedro; Borges, Vítor; Sousa, Carlos; Ferreira, Bibiana I.; Fonte, Ana; Fernandes, Eugénia; Dias, Carlos Matias; Duarte, Sílvia

We estimated comparative primary and booster vaccine effectiveness (VE) of SARS-CoV-2 Omicron BA.5 and BA.2 lineages against infection and disease progression. During April-June 2022, we implemented a case-case and cohort study and classified lineages using whole-genome sequencing or spike gene target failure. For the case-case study, we estimated the adjusted odds ratios (aORs) of vaccination using a logistic ...


Comparative complete scheme and booster effectiveness of COVID‐19 vaccines in p...

Kislaya, Irina; Peralta‐Santos, André; Borges, Vítor; Vieira, Luís; Sousa, Carlos; Ferreira, Bibiana; Pelerito, Ana; Gomes, João Paulo

Background: Information on vaccine effectiveness in a context of novel variants of concern (VOC) emergence is of key importance to inform public health policies. This study aimed to estimate a measure of comparative vaccine effectiveness between Omicron (BA.1) and Delta (B.1.617.2 and sub-lineages) VOC according to vaccination exposure (primary or booster). Methods: We developed a case–case study using data on ...


Delta variant and mRNA COVID-19 vaccines effectiveness: higher odds of vaccine ...

Kislaya, Irina; Freire Rodrigues, Eduardo; Borges, Vítor; Gomes, João Paulo; Sousa, Carlos; Almeida, José Pedro; Peralta-Santos, André; Nunes, Baltazar

Information on COVID-19 vaccines' effectiveness and viral loads in vaccine infection breakthrough cases are critical to inform decision-makers. Few studies have compared the effectiveness of mRNA vaccines against Delta versus Alpha variant of concern (VOC) and estimated variant-specific viral loads in vaccine infection breakthroughs cases. We developed a case-case study to compare mRNA vaccines' effectiveness a...



Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spi...

Borges, Vítor; Sousa, Carlos; Menezes, Luís; Gonçalves, António Maia; Picão, Miguel; Almeida, José Pedro; Vieita, Margarida; Santos, Rafael

We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statisti...


The Impact of Electronic Monitoring on Healthcare Associated Infections: The Ro...

de Oliveira, Rita Fontes; Castro, Lídia; Almeida, José Pedro; Alves, Carlos; Ferreira, António

Introduction: In Portugal, 9.8% of patients admitted were inflicted with healthcare associated infections, corresponding to a prevalence of 11.7%. The Hospital de São João has developed a business intelligence platform able to supervise (the patients), monitor (the clinical condition) and notify (the healthcare personnel): HViTAL. This study aims to assess the impact of electronic monitoring on healthcare assoc...

Date: 2016   |   Origin: Acta Médica Portuguesa

Aging and muscle strength in patients with type 2 diabetes: cross sectional ana...

Almeida, José Pedro; Almeida, António; Alves, Josiane Teixeira; Saavedra, F. J.; Sousa, Nelson; Mendes, Romeu

Date: 2016   |   Origin: Repositório da UTAD

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