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In vitro and in vivo analysis of RTK inhibitor efficacy and identification of i...
Martinho, Olga; Oliveira, Renato José Silva; Gonçalves, Vera M.; Clara, Carlos; Almeida, José Reynaldo; Carvalho, André Lopes; Barata, João TabordaTreatment for glioblastoma consists of radiotherapy and temozolomide-based chemotherapy. However, virtually all patients recur, leading to a fatal outcome. Receptor tyrosine kinase (RTK)-targeted therapy has been the focus of attention in novel treatment options for these patients. Here, we compared the efficacy of imatinib, sunitinib, and cediranib in glioblastoma models. In the present work, the biologic effe...
Date: 2013
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Origin: RepositóriUM - Universidade do Minho