4 documents found, page 1 of 1
Vulvovaginal candidiasis and asymptomatic vaginal colonization in Portugal: Epi...
Fernandes, Ângela; Azevedo, Nuno Miguel Morais; Valente, Andreia; Dias, Marisol; Gomes, Ana; Nogueira-Silva, Cristina; Henriques, MarianaVulvovaginal candidiasis (VVC) has been identified as a global issue of concern due to its clinical, social and economic implications. The emerging relevance of VVC makes it crucial to increase the knowledge on its epidemiological and etiological features in order to improve its prevention and treatment. Thus, this study aimed to reveal the incidence, microbiology, antifungal pattern and risk factors of VVC in ...
Transcriptional responses of Candida glabrata biofilm cells to fluconazole are ...
Alves, R.; Kastora, Stavroula L.; Gomes-Gonçalves, Alexandra; Azevedo, Nuno Miguel Morais; Rodrigues, Célia F.; Silva, Sónia Carina; Demuyser, LiesbethCandida glabrata is an important human fungal pathogen known to trigger serious infections in immune-compromised individuals. Its ability to form biofilms, which exhibit high tolerance to antifungal treatments, has been considered as an important virulence factor. However, the mechanisms involving antifungal resistance in biofilms and the impact of host niche environments on these processes are still poorly def...
Hormones modulate Candida vaginal isolates biofilm formation and decrease their...
Gonçalves, Bruna Fernandes; Azevedo, Nuno Miguel Morais; Henriques, Mariana; Silva, Sónia CarinaVulvovaginal candidiasis (VVC) is an infection usually caused by Candida albicans and increasingly by Candida glabrata, which has an intrinsically high resistance to commonly used antifungals. Candida species possess virulence factors that contribute to VVC development, as the ability to form biofilms in vaginal walls and intrauterine devices. It is known that VVC is promoted by conditions that increase the hor...
Antisense therapy to control adhesion and filamentation of Candida albicans
Azevedo, Nuno Miguel MoraisThe incidence of fungal infections has increased significantly in the last years, contributing to the augment of morbidity and mortality in health care system. A raise in antimicrobial resistance, the number of immunosuppressive patients and the restricted number of antifungal drugs are the most common causes of these infections, where Candida species are the major responsible. The prevalence of these opportuni...