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Retrospective detection and genetic characterization of Porcine circovirus 3 (p...
Saraiva, Giuliana Loreto; Vidigal, Pedro Marcus Pereira; Assao, Viviane Sisdelli; Fajardo, Murilo Leone Miranda; Loreto, Alerrandra Nunes SaraivaPorcine circovirus 3 (PCV3) is an emerging virus that was first identified in the United States in 2016. Since its first detection, PCV3 has already been found in America, Asia, and Europe. Although PCV3 has already been described in Brazil, knowledge of its detection and sequence variation before 2016 is limited, as well as its distribution in the main swine producing regions of Brazil. In this study, 67 porci...
Imunogenicidade de isolados de herpesvírus bovino 5 como candidatos à vacina
Souza, Luiz Felipe Lourenço de; Silva Júnior, Abelardo; Freitas, Carla Maria Batista de; Flores, Eduardo Furtado; Almeida, Márcia Rogéria deO herpesvírus bovino 5 (BoHV-5) é o agente da menigoencefalite herpética bovina. A doença neurológica, associada à infecção pelo BoHV-5, apresenta altas taxas de letalidade em bovinos jovens e está disseminada no Brasil. A prevenção das perdas causadas pela infecção pelo herpesvírus está baseada, principalmente, na imunização dos animais. Nesse sentido, foi delineada uma comparação entre isolados de BoHV-5, bus...
Evaluation of the antiviral activities of Bacharis dracunculifolia and querceti...
Ferreira, Caroline Gracielle Torres; Campos, Mateus Gandra; Felix, Daniele Mendes; Santos, Marcus Rebouças; Carvalho, Otávio Valério deEquid herpesvirus 1 (EHV-1) is a pathogen of high economic importance in equine breeding operations around the world. EHV-1 infection causes respiratory, neurologic and reproductive disease. The absence of an efficient therapy has caught the attention of the scientific community and the therapeutic activities of natural products with its antivirals effects might be effective for the disease's treatment. Herein ...
Distribution of infectious bronchitis virus strains in different organs and evi...
Pereira, Claiton Gonçalves; Saraiva, Giuliana Loreto; Vidigal, Pedro Marcus Pereira; Fietto, Juliana Lopes Rangel; Bressan, Gustavo CostaOn the basis of partial sequencing of the infectious bronchitis virus (IBV) S1 gene, this study investigated the molecular diversity of the virus in two life periods of a batch of breeding hens at the field level. The chicks were vaccinated against IBV on the second day of life with the vaccine Ma5, but at the age of 18 days, they exhibited clinical signs and macroscopic lesions compatible with avian infectious...
Antibodies against Bovine herpesvirus 1 in dairy herds in the state of Espirito...
Santos, Marcus Rebouças; Ferreira, Hanna Carolina Campos; Santos, Marcos Antônio dos; Saraiva, Giuliana Loreto; Tafuri, Natália FilardiO herpesvírus bovino 1 (Bovine herpesvirus 1 - BoHV-1) causa grandes prejuízos econômicos à pecuária bovina mundial, por comprometer os sistemas respiratório e reprodutivo de bovinos de corte e leiteiros. Nas últimas décadas, os registros de casos clínicos ocasionados pelo BoHV-1, no Brasil, mostram que têm aumentado gradualmente, o que torna importante o delineamento de estudos que mostrem a distribuição da in...
Verification of natural infection of peridomestic rodents by PCV2 on commercial...
Pinheiro, Albanno Leonard Braz Campos; Bulos, Luiz Henrique Silva; Onofre, Thiago Souza; Gabardo, Michelle de Paula; Carvalho, Otávio Valério deThe porcine circovirus-2 (PCV2) is the main agent responsible for porcine circovirus associated diseases (PCVAD). Few studies have been done regarding PCV2 infection in other species. The purpose of this study was to investigate the occurrence of PCV2 infection in the peridomestic rodent species Mus musculus and Rattus rattus on commercial pig farms in Brazil. Immunohistochemistry assay demonstrated PCV2 in the...
Evolutionary analysis of porcine circovirus 3 (PCV3) indicates an ancient origi...
Saraiva, Giuliana Loreto; Vidigal, Pedro Marcus Pereira; Fietto, Juliana Lopes Rangel; Bressan, Gustavo Costa; Silva Júnior, AbelardoPorcine circovirus 3 (PCV3) is an emerging virus that was identified in the United States in 2016. Since its first identification, PCV3 has been identified in Brazil, China, United States, Poland, and Republic of Korea. In this study, we used molecular phylogenetic analysis of available sequences to address questions surrounding the emergence of PCV3 in porcine world industry. Our data indicate that PCV3 did no...
Utilization of phage display to identify antigenic regions in the PCV2 capsid p...
Santos, Marcus Rebouças; Assao, Viviane Sisdelli; Salgado, Rafael Locatelli; Fietto, Juliana Lopes Rangel; Bressan, Gustavo CostaPorcine circovirus 2 (PCV2) is associated with a series of swine diseases. There is a great interest in improving our understanding of the immunology of PCV2, especially the properties of the viral capsid protein Cap-PCV2 and how they relate to the immunogenicity of the virus and the subsequent development of vaccines. Phage display screening has been widely used to study binding affinities for target proteins....
Evaluation of the genetic variability found in Brazilian commercial vaccines fo...
Saraiva, Giuliana Loreto; Santos, Marcus Rebouças; Pereira, Claiton Gonçalves; Vidigal, Pedro Marcus Pereira; Fietto, Juliana Lopes RangelInfectious bronchitis virus (IBV) is currently one of the most important pathogens in the poultry industry. The H120 and Ma5 are the only viral strains approved by the Brazilian government as the constituent of vaccines. Despite the systematic vaccination in Brazil, IBV has not yet been controlled and diseases associated with this virus have been reported in vaccinated chickens. Here, we investigated the geneti...
Trypanosoma cruzi nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase-1) bi...
Mariotini-Moura, Christiane; Bastos, Matheus Silva e; Castro, Felipe Freitas de; Trindade, Mellina Lanna; Vasconcellos, Raphael de SouzaPrevious work has suggested that Trypanosoma cruzi diphosphohydrolase 1 (TcNTPDase-1) may be involved in the infection of mammalian cells and serve as a potential target for rational drug design. In this work, we produced recombinant TcNTPDase-1 and evaluated its nucleotidase activity, cellular localization and role in parasite adhesion to mammalian host cells. TcNTPDase-1 was able to utilize a broad range of t...