9 documents found, page 1 of 1
Targeting p53 for melanoma treatment: Counteracting tumour proliferation, disse...
Loureiro, JB; Raimundo, L; Calheiros, J; Carvalho, C; Barcherini, V; Lima, NR; Gomes, C; Almeida, MI; Alves, MG; Costa, JL; Santos, MMM; Saraiva, LMelanoma is the deadliest form of skin cancer, primarily due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagenesis may predict promising outcomes for p53 activators in melanoma therapy. Herein, we aimed to investigate the antitumor potential of the p53-activating agent SLMP53-2 against melanoma. Two-and ...
Circulating micrornas correlate with multiple myeloma and skeletal osteolytic l...
Moura, SR; Abreu, H; Cunha, C; Ribeiro-Machado, C; Oliveira, CM; Barbosa, MA; Marques, H; Almeida, MIMultiple myeloma (MM) is the second most frequent hematological disease and can cause skeletal osteolytic lesions. This study aims to evaluate the expression of circulating microRNAs (miR-NAs) in MM patients and to correlate those levels with clinicopathological features, including bone lesions. A panel of miRNAs associated with MM onset and progression, or with bone remodeling, was analyzed in the plasma of 82...
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signal...
Bras, JP; Bravo, J; Freitas, J; Barbosa, MA; Santos, SG; Summavielle, T; Almeida, MIGrowing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders. In some pathological conditions, microglia produce increased levels of cytotoxic and inflammatory mediators, such as tumor necrosis factor alpha (TNF-a), which can reactivate microglia in a positive feedback mechanism....
Long noncoding RNAs: a missing link in osteoporosis
Silva, AM; Moura, SR; Teixeira, JH; Barbosa, MA; Santos, SG; Almeida, MIOsteoporosis is a systemic disease that results in loss of bone density and increased fracture risk, particularly in the vertebrae and the hip. This condition and associated morbidity and mortality increase with population ageing. Long noncoding (lnc) RNAs are transcripts longer than 200 nucleotides that are not translated into proteins, but play important regulatory roles in transcriptional and post-transcript...
The systemic immune response to collagen-induced arthritis and the impact of bo...
Teixeira, JH; Silva, AM; Almeida, MI; Bessa-Gonçalves, M; Cunha, C; Barbosa, MA; Santos, SGRheumatoid arthritis (RA) is a systemic disease that affects the osteoarticular system, associated with bone fragility and increased risk of fractures. Herein, we aimed to characterize the systemic impact of the rat collagen-induced arthritis (CIA) model and explore its combination with femoral bone defect (FD). The impact of CIA on endogenous mesenchymal stem/stromal cells (MSC) was also investigated. CIA indu...
Genetically engineered-MSC therapies for non-unions, delayed unions and critica...
Freitas, J; Santos, SG; Gonçalves, RM; Teixeira, JH; Barbosa, MA; Almeida, MIThe normal bone regeneration process is a complex and coordinated series of events involving different cell types and molecules. However, this process is impaired in critical-size/large bone defects, with non-unions or delayed unions remaining a major clinical problem. Novel strategies are needed to aid the current therapeutic approaches. Mesenchymal stem/stromal cells (MSCs) are able to promote bone regenerati...
SLMP53-2 restores wild-type-like function to mutant p53 through hsp70: Promisin...
Gomes, S; Bosco, B; Loureiro, JB; Ramos, H; Raimundo, L; Soares, J; Nazareth, N; Barcherini, V; Domingues, L; Oliveira, C; Bisio, A; Piazza, SHalf of human cancers harbor TP53 mutations that render p53 inactive as a tumor suppressor. In these cancers, reactivation of mutant p53 (mutp53) through restoration of wild-type-like function constitutes a valuable anticancer therapeutic strategy. In order to search for mutp53 reactivators, a small library of tryptophanol-derived oxazoloisoindolinones was synthesized and the potential of these compounds as mut...
Profiling the circulating miRnome reveals a temporal regulation of the bone inj...
Silva, AM; Almeida, MI; Teixeira, JH; Ivan, C; Oliveira, J; Vasconcelos, DM; Neves, N; Ribeiro-Machado, C; Cunha, C; Barbosa, MA; Calin, G; Santos, SGBone injury healing is an orchestrated process that starts with an inflammatory phase followed by repair and remodelling of the bone defect. The initial inflammation is characterized by local changes in immune cell populations and molecular mediators, including microRNAs (miRNAs). However, the systemic response to bone injury remains largely uncharacterized. Thus, this study aimed to profile the changes in the ...
Detection of the Epstein-Barr virus in blood and bone marrow mononuclear cells ...
Marques, H; Catarino, R; Domingues, N; Barros, E; Portela, C; Almeida, MI; Costa, S; Reis, RM; Medeiros, R; Longatto-Filho, AThe Epstein-Barr virus (EBV) is associated with a large spectrum of lymphoproliferative diseases. Traditional methods of EBV detection include the immunohistochemical identification of viral proteins and DNA probes to the viral genome in tumoral tissue. The present study explored the detection of the EBV genome, using the BALF5 gene, in the bone marrow or blood mononuclear cells of patients with diffuse large B...