22 documents found, page 1 of 3

INSPEÇÃO VISUAL A CINCO ZONAS DAS MURALHAS DE ALCÁCER DO SAL

A localização de Alcácer do Sal, nas margens do rio Sado, num território abundante em recursos naturais, permitiu que a sua ocupação fosse bastante desejada, o que levou ao longo do tempo, à fixação de diversos povos. A imponente fortificação militar, edificada no ponto mais alto da povoação, os vestígios materiais e o topónimo que dá nome à cidade, são marcas que, sem dúvida, demarcam o contributo e ocupação d...

Innovative technological resources for Alzheimer's disease care management: A s...

Objective: The aim of this scoping review was to map and describe the technological tools reported in the literaturethat have been designed for care management in Alzheimer’s disease, with a particular focus on supporting patients livingwith the condition, their families, caregivers, and healthcare professionals.Methods: The review was conducted in accordance with the PRISMA (Preferred Reporting Items for Syste...

Locust bean gum (LBG) – a potential excipient for inhalation purposes: excipien...

Dry powders proposed for lung drug delivery typically involve excipients not approved for inhalation. The physicochemical characterisation of excipients is informative regarding their interaction with different body structures. Locust Bean Gum (LBG) has been proposed for diverse applications, including inhalation, benefiting from targeting ability towards phagocytic cells owing to the presence of mannose moieti...

The role of reactive oxygen species in bone cell physiology and pathophysiology

Hydrogen peroxide (H2O2), superoxide anion radical (O2-•), and other forms of reactive oxygen species (ROS) are produced by the vast majority of mammalian cells and can contribute both to cellular homeostasis and dysfunction. The NADPH oxidases (NOX) enzymes and the mitochondria electron transport chain (ETC) produce most of the cellular ROS. Multiple antioxidant systems prevent the accumulation of excessive am...

The NAD salvage pathway in mesenchymal cells is indispensable for skeletal deve...

NAD is an essential co-factor for cellular energy metabolism and multiple other processes. Systemic NAD+ deficiency has been implicated in skeletal deformities during development in both humans and mice. NAD levels are maintained by multiple synthetic pathways but which ones are important in bone forming cells is unknown. Here, we generate mice with deletion of Nicotinamide Phosphoribosyltransferase (Nampt), a ...

Eficácia da intervenção da osteopatia nas disfunções ginecológicas: uma revisão...

Os distúrbios ginecológicos apresentam elevada prevalência e têm como possíveis consequências o aumento da dor e a diminuição da qualidade de vida. Apesar do tratamento ser maioritariamente farmacológico, cada vez mais a osteopatia se tem afirmado como uma forma de tratamento válida e eficaz. Sistematizar os ensaios clínicos randomizados de forma a verificar a eficácia da intervenção osteopática na dor e qualid...

PRINCIPAIS DESAFIOS NO ENSINO-APRENDIZAGEM DE BOTÂNICA NA VISÃO DE UM GRUPO DE ...

Submitted by Yanna Sousa (yanna_gomes@yahoo.com.br) on 2021-08-04T12:10:11Z No. of bitstreams: 2 Ata de defesa_Auta Paulina da Silva.pdf: 168939 bytes, checksum: e6188309caec51eff7b871f550713913 (MD5) PRINCIPAIS DESAFIOS NO ENSINO-APRENDIZAGEM DE BOTÂNICA NA VISÃO DE UM GRUPO DE PROFESSORES DA EDUCAÇÃO BÁSICA_Auta Paulina.pdf: 677067 bytes, checksum: f2678be7a4021f152928b7f4bc569275 (MD5); Approved for entry in...

Estrogens decrease osteoclast number by attenuating mitochondria oxidative phos...

Loss of estrogens at menopause is a major cause of osteoporosis and increased fracture risk. Estrogens protect against bone loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage. Here, we investigated the molecular mechanism of this effect. We report that 17β-estradiol (E2) decreased osteoclast number by promoting the apoptosis of early osteoclast progenitors, but not matur...

Effects of caregiver-provided individual cognitive interventions on cognition, ...

Objective: The objective of this review was to investigate the effectiveness of caregiver-provided individual cognitive interventions for improving cognition, social functioning and quality of life in older adults with major neurocognitive disorders. Introduction: A large number of people with major neurocognitive disorders live in their homes, requiring ongoing community care. Different individual cognitive in...

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