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Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medic...

dos Santos, Catarina Ferreira; Gomes, Pedro Sousa; Almeida, Maria Margarida; Willinger, Marc-Georg; Franke, Ralf-Peter; Fernandes, Maria Helena

A novel synthetic approach for coupling metallic gold nanoparticles (AuNPs) to the facets of hydroxyapatite crystalline nanoparticles (HapNPs) without an additional reducing agent was developed. Hexagonal prism-shaped hydroxyapatite nanoparticles (HapNPs) were first precipitated by a hydrothermal route assisted by citric acid, which left behind carboxylate species adsorbed on the HapNP facets. HapNP were then u...


Morphological Evolution of Hydroxyapatite Particles in the Presence of Differen...

Santos, Catarina; Almeida, Maria Margarida; Costa, Maria Elisabete

This work is focused on the potential role of citrate-derived species as tailoring agents for the morphology of hydroxyapatite particles during their synthesis. Under hydrothermal conditions (T = 180 degrees C), precursor solutions with different initial citrate:calcium molar ratios (R) allow the nucleation and growth of hydroxyapatite particles whose final morphology shows a significant dependence on the initi...


Complex Effect of Hydroxyapatite Nanoparticles on the Differentiation and Funct...

Costa-Rodrigues, Joao; Silva, Ana; Santos, Catarina; Almeida, Maria Margarida; Costa, Maria Elisabete; Fernandes, Maria Helena

Nanosized hydroxyapatite (HA) is a promising material in clinical applications targeting the bone tissue. NanoHA is able to modulate bone cellular events, which accounts for its potential utility, but also raises safety concerns regarding the maintenance of the bone homeostasis. This work analyses the effects of HA nanoparticles (HAnp) on osteoclastic differentiation and activity, an issue that has been barely ...


Bateria de avaliação do temperamento infantil – forma revista

Almeida, Maria Margarida; Seabra-Santos, Maria João; Major, Sofia

Numerous studies suggest that temperament may be considered a particularly useful variable in the understanding of interactions between children and their social environment. In this context the assessment of temperament has progressively been highlighted as an important component of the psychological assessment of children. In this paper we present the questionnaire Temperament Assessment Battery for Children ...

Date: 2010   |   Origin: Psychologica

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