38 documents found, page 1 of 4

"Mannose glycans as key players in trained immunity: A novel anti-tumoral catal...

Cell wall glycans isolated from microorganisms are long known to provoke strong immune responses piloted by innate immune cell populations, including monocytes, in the context of Trained Immunity (TI). However, the contribution of yeast-derived mannan in the reprogramming of monocytes remains ill-defined. Here, we demonstrated that TI is often accompanied by an altered gene expression profile of selected glycan...

Reprogramming CD8+ T-cell Branched N-Glycosylation Limits Exhaustion, Enhancing...

T-cell therapies have transformed cancer treatment. While surface glycans have been shown to play critical roles in regulating T-cell development and function, whether and how the glycome influences T cell–mediated tumor immunity remains an area of active investigation. In this study, we show that the intratumoral T-cell glycome is altered early in human colorectal cancer, with substantial changes in branched N...

Glycans in Trained Immunity: Educators of innate immune memory in homeostasis a...

Trained Immunity is defined as a biological process normally induced by exogenous or endogenous insults that triggers epigenetic and metabolic reprogramming events associated with long-term adaptation of innate immune cells. This trained phenotype confers enhanced responsiveness to subsequent triggers, resulting in an innate immune "memory" effect. Trained Immunity, in the past decade, has revealed important be...

Evaluation of the quality of life and associated factors of a group of children...

Introduction: Children/adolescents with cystic fibrosis (CF) have psychological and physical difficulties that have a severe impact on their health-related quality of life (HRQoL). Aim: To evaluate the impact of CF on HRQoL in a pediatric age sample by identifying major determinants and comparing the HRQoL reports of children and their parents. Methods: A sample of 27 children/adolescents was included in a cros...

The UriCath Study: Characterization of the Use of Indwelling Urinary Catheters ...

Purpose: Approximately 25% of older inpatients have an indwelling urinary catheter (IUC), 45-54% unnecessarily. This study aims to describe the prevalence, indications, and complications of IUC use in Portuguese older inpatients. Methods: Multicentric, cross-sectional, observational study conducted in Portuguese internal medicine wards (UriCath). Results: Of a total of 3135 inpatients from 39 hospitals, we incl...

Alimentação na Demência Avançada: Documento de Consenso da Sociedade Portuguesa...

Management of Pipkin Fractures Using a Safe Surgical Hip Dislocation

INTRODUCTION: Pipkin fractures are rare events and usually occur as a consequence for high-energy trauma. Surgery to obtain anatomical reduction and fixation is the mainstay treatment for the majority of these injuries; nonetheless, controversy exists regarding the best surgical approach. DESCRIPTION OF THE CASE: We present the case of a 41-year-old male, which sustained a type II Pipkin fracture following a mo...

Mothers' eating styles influence on their feeding practices and on their childr...

<jats:p>Background: Overweight and obesity in children and adolescents has become an important public health concern in the last decades. To study the way mothers and childrens behavioral factors interact with each other, influencing eating and body weight, may provide information to be used in preventive and treatment strategies.Goals: To study the association of mothers eating style on their feeding behavior ...

Ultrasound requested by general practitioners or for symptoms unrelated to the ...

BACKGROUND: A higher prevalence of thyroid nodules/carcinoma in females is well-known from the literature. The reasons for this difference are not fully explained. We intended to assess gender variation in the referral for ultrasound-guided fine needle aspiration (FNA) of thyroid nodules, to study reasons for gender referral differences, and to assess differences in nodules characteristics between genders. METH...

Ultrasound Requested by General Practitioners or for Symptoms Unrelated to the ...

Background: A higher prevalence of thyroid nodules/carcinoma in females is well-known from the literature. The reasons for this difference are not fully explained. We intended to assess gender variation in the referral for ultrasound-guided fine needle aspiration (FNA) of thyroid nodules, to study reasons for gender referral differences, and to assess differences in nodules characteristics between genders. Meth...