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TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related int...
Wong, Deysi Viviana Tenazoa; Holanda, Renata Brito Falcão; Cajado, Aurilene Gomes; Bandeira, Alessandro Maia; Pereira, Jorge Fernando BessaMade available in DSpace on 2022-05-01T07:58:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico; Background and purpose: Severe diarrhoea, a common gastrointestinal manifestation of anticanc...
Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats
Macedo, Francisco Yuri Bulcao; Baltazar, Fátima; Almeida, Paulo Roberto Carvalho; Távora, Fábio; Ferreira, Francisco Valdeci; Schmitt, Fernando C.Purpose Hemorrhagic cystitis (HC) is a limiting side effect of chemotherapy with ifosfamide (IFS). In this study, we investigated the participation of cyclooxygenase-2 (COX-2) upon ifosfamide-induced HC. Methods Male Wistar rats (150-200 g; six rats per group) were treated with saline, IFS (400 mg/kg, i.p.) and analyzed by changes in bladder wet weight, macroscopic and microscopic parameters, and COX-2 expressi...