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Leishmanicidal and cytotoxic activity of hederagenin-bistriazolyl derivatives
Rodríguez-Hernández, Diego; Barbosa, Luiz C.A.; Demuner, Antonio J.; Nain-Perez, Amalyn; Ferreira, Sebastião R.; Fujiwara, Ricardo T.Aiming to obtain new potent leishmanicidal and cytotoxic compounds from natural sources, the triterpene hederagenin was converted into several new 1,2,3-triazolyl derivatives tethered at C-23 and C-28. For this work hederagenin was isolated from fruits of Sapindus saponaria and reacted with propargyl bromide to afford as a major product bis-propargylic derivative 1 in 74%. Submitting this compound to Huisgen 1,...
Date: 2018
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Origin: Oasisbr