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Highly potent anti-leishmanial derivatives of hederagenin, a triperpenoid from ...
Rodríguez-Hernández, Diego; Barbosa, Luiz C.A.; Demuner, Antonio J.; Almeida, Raquel M.de; Fujiwara, Ricardo T.; Ferreira, Sebastião R.Leishmaniasis is a neglected tropical disease (NTDs), endemic in 88 countries that affect more than 12 million people. Current drugs are limited due to their toxicity, development of biological resistance, length of treatment and high cost. Thus, the search for new effective and less toxic treatments is an urgent need. In this study, we report the synthesis of 3 new amide derivatives of hederagenin (22–24) with...
Date: 2018
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Origin: Oasisbr