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Preparation, characterization, and pharmacological activity of Cymbopogon winte...
Santos, Priscila Laíse dos; Araujo, Adriano Antunes de Souza; Quintans, Jullyana de Souza Siqueira; Brito, Renan Guedes de; Serafini, Mairim RussoThis study aimed to evaluate the orofacial antinociceptive effect of the Cymbopogon winterianus essential oil (LEO) complexed in B-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS). The LEO was extracted, chromatographed, and complexed in B-cyclodextrin. The complex was characterized by differential scanning calorimetry (DSC) and thermogravimetry derivative (TG/DTG...
Phytochemical screening and anticonvulsant property of Ocimum basilicum leaf es...
Oliveira, Juliana S.; Porto, Lívia A.; Estevam, Charles dos Santos; Siqueira, Rosana de Souza; Barreto, Péricles Barreto; Niculau, Edenilson dos SantosOcimum basilicum (Lamiaceae) and other species of the same genus are used as medicines for the treatment of central nervous system (CNS) diseases. In this report, we have investigated the possible CNS depressant and anticonvulsant effects of Ocimum basilicum (access “Maria Bonita”) leaf essential oil (EO) in different experimental models. GC-MS and GC-FID analysis of the essential oil resulted in the identifica...
Carvacrol, (−)-borneol and citral reduce convulsant activity in rodents
Quintans-Júnior, Lucindo José; Guimarães, Adriana Gibara; Araújo, Bruno Eduardo Silva de; Cavalcanti, Sócrates Cabral de HolandaCarvacrol, a monoterpenic phenol present in essential oils of the Labiatae family, has been used through the ages as a source of flavor in food and for medicinal purposes. Borneol is a monoterpene found in several species of Artemisia and Dipterocarpaceae, used for anxiety, pain and anesthesia in traditional Chinese. Citral, a mixture of two geometrical isomers (neral and geranial), is one of the most important...
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of centr...
Quintans-Júnior, Lucindo José; Silva, Davi Alves da; Quintans, Jullyana de Souza Siqueira; Araújo, Adriano Antunes de Souza; Guimarães, Adriana GibaraAIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated ...
Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine:...
Quintans-Júnior, Lucindo José; Silva, Davi Antas; Quintans, Jullyana de Souza Siqueira; Araújo, Adriano Antunes de Souza; Siqueira, Rosana de SouzaWe investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the...