4 documents found, page 1 of 1
BRCAness as a biomarker of susceptibility to PARP inhibitors in glioblastoma mu...
Xavier, Mary-Ann Elvina; Rezende, Fernando; Almeida, Ricardo Titze de; Cornelissen, BartGlioblastoma multiforme (GBM) is the most common primary brain cancer. GBMs commonly acquire resistance to standard-of-care therapies. Among the novel means to sensitize GBM to DNA-damaging therapies, a promising strategy is to combine them with inhibitors of the DNA damage repair (DDR) machinery, such as inhibitors for poly(ADP-ribose) polymerase (PARP). PARP inhibitors (PARPis) have already shown efficacy and...
Delivery of miRNA-targeted oligonucleotides in the rat striatum by magnetofecti...
Almeida, Simoneide Souza Titze de; Horst, Camila Hillesheim; Sánchez, Cristina Soto; Fernandez, Eduardo; Almeida, Ricardo Titze deMicroRNAs (miRNAs) regulate gene expression at posttranscriptional level by triggering RNA interference. In such a sense, aberrant expressions of miRNAs play critical roles in the pathogenesis of many disorders, including Parkinson’s disease (PD). Controlling the level of specific miRNAs in the brain is thus a promising therapeutic strategy for neuroprotection. A fundamental need for miRNA regulation (either re...
Molecular epidemiology and antimicrobial susceptibility of enterococci recovere...
Almeida, Ricardo Titze de; Rollo Filho, Maurício; Silveira, Celeste Aída Nogueira; Rodrigues, Isabela Pereira; Eudes Filho, JoãoABSTRACT: We studied the antimicrobial resistance and the molecular epidemiology of 99 enterococcal surveillance isolates from two hospitals of Brasília, Brazil. Conventional biochemical tests were used to identify the enterococcal species and the disk diffusion method was used to determine their resistance profiles. Enterococcus faecalis (76%) and E. faecium (9%) were the most prevalent species. No enterococci...
Rapid detection of Vancomycin-Resistant Enterococci (VRE) in rectal samples fro...
d'Azevedo, Pedro Alves; Santiago, Kelly Aline de Souza; Furtado, Guilherme Henrique Campos; Xavier, Diego Batista; Pignatari, Antonio Carlos CamposABSTRACT: The reduction in time required to identify vancomycin-resistant enterococci (VRE) has gained increased importance during hospital outbreaks. In the present study, we implemented a laboratory protocol to speed up the VRE screening from rectal samples. The protocol combines a medium for selective VRE isolation (VREBAC®, Probac, São Paulo) and a multiplex PCR for detection and identification of vanA and ...