41 documents found, page 1 of 5

Relatório científico da Expedição Oceano Azul - Cascais | Mafra | Sintra

A zona marítima dos concelhos de Cascais, Mafra e Sintra tem sido pouco estudada, não obstante situar-se frente a grandes centros urbanos e ser alvo de diversos usos e atividades humanas. Algumas das suas características geográficas e dos seus elementos notáveis ao nível dos fundos marinhos acrescem o seu interesse científico e patrimonial. Com o objectivo de ampliar o conhecimento científico sobre a biodiversi...

Seroprevalence of Protective Antibodies Against Influenza and the Reduction of ...

Background: Seroepidemiological studies provide estimates of population-level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. We assessed the seroprevalence of protective antibodies against influenza and evaluated the correlation of seroprevalence with the cumulative annual influenza incidence rate. Methods: We conducted an annual repeated cross-sectional seroepidemiologica...

Acute Coronary Syndrome and Stress: Is There a Relationship?

Introduction: Acute coronary syndrome (ACS) is the result of a complex pathophysiological process with various dynamic factors. The 10-item Perceived Stress Scale (PSS-10) is a validated instrument for estimating stress levels in clinical practice and may be useful in the assessment of ACS. Methods: We carried out a single-center prospective study engaging patients hospitalized with ACS between March 20, 2019 a...

Anxiety and depression symptoms after pulmonary rehabilitation in people with i...

Pulmonary rehabilitation (PR) is an effective intervention for people with interstitial lung disease (ILD), as it improvesexercise capacity, quality of life and dyspnoea. Less is, however, known about other important and frequentsymptoms, such as anxiety and depression. This study explored the response of anxiety and depression symptomsto PR in people with ILD. Participants undertook a 12-week community-based P...

Emotion-Focused Therapy for fear of cancer recurrence: a hospital-based explora...

Physical Interactions With Bacteria and Protozoan Parasites Establish the Scave...

Since the pioneering discoveries, by the Nobel laureates Jules Hoffmann and Bruce Beutler, that Toll and Toll-like receptors can sense pathogenic microorganisms and initiate, in vertebrates and invertebrates, innate immune responses against microbial infections, many other families of pattern recognition receptors (PRRs) have been described. One of such receptor clusters is composed by, if not all, at least sev...

Modulation of CD4 T cell function via CD6-targeting

In recent years molecules involved on the immune synapse became successful targets for therapeutic immune modulation. CD6 has been extensively studied, yet, results regarding CD6 biology have been controversial, in spite of the ubiquitous presence of this molecule on virtually all CD4 T cells. We investigated the outcome of murine and human antibodies targeting CD6 domain 1. We found that CD6-targeting had a ma...

Pazopanib-Induced Cutaneous Leukocytoclastic Vasculitis: An Exclusion Diagnosis...

In phase II/III trials, cutaneous side effects of pazopanib were reported in less than 20% of patients, with only 1-3% being grade 3/4. We present a case of a 66-year-old man with a previous history of left nephrectomy for a stage II clear cell renal carcinoma. Approximately 18 months later, recurrent disease in the lungs, mediastinum, and left psoas and bulky abdominal/pelvic nodal metastasis were documented. ...

O Repositório e o Anuário do Centro Hospitalar de Lisboa Central: Contributos P...

Numa unidade de saúde, a atividade científica tem reconhecidas vantagens para a assistência clínica, investigação e ensino/formação. Têm sido adoptadas diversas estratégias para obter um registo completo da produção científica do CHLC, mas também para permitir o acesso aberto da ciência aos seus colaboradores. Assim, o Centro Hospitalar de Lisboa Central (CHLC) aderiu à rede de Repositórios Científicos de Acess...

Anthropometric features as predictors of atherogenic dyslipidemia and cardiovas...

Background: Autopsy studies reveal that atherosclerosis lesions can be found as early as two years of age. To slow the development of this early pathology, obesity and dyslipidemia prevention should start from childhood making it urgent to explore new ways to evaluate dyslipidemia risk in children that can be applied widely, such as the non-invasive anthropometric evaluation. Objective: Assess the metabolic pro...