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Clinical Impact of the Line Probe Assay and Xpert® MTB/RIF Assay in the Presump...
Kritski,Afranio; Oliveira,Maria Martha; Almeida,Isabela Neves de; Ramalho,Daniela; Andrade,Monica Kramer de Noronha; Carvalho,MonicaABSTRACT Background: Rapid molecular methods such as the line probe assay (LPA) and Xpert® MTB/RIF assay (Xpert) have been recommended by the World Health Organization for drug-resistant tuberculosis (DR-TB) diagnosis. We conducted an interventional trial in DR-TB reference centers in Brazil to evaluate the impact of the use of LPA and Xpert. Methods: Patients with DR-TB were eligible if their drug susceptibili...
Cost-effectiveness of Xpert®MTB/RIF in the diagnosis of tuberculosis: pragmatic...
Silva,Suely Conceição Alves da; Vater,Maria Claudia; Ramalho,Daniela Maria de Paula; Almeida,Isabela Neves de; Miranda,Silvana Spíndola deAbstract INTRODUCTION: The intensification of research and innovation with the creation of networks of rapid and effective molecular tests as strategies for the end of tuberculosis are essential to avoid late diagnosis and for the eradication of the disease. We aimed to evaluate the cost-effectiveness of Xpert®MTB/RIF (Xpert) in the diagnosis of drug-resistant tuberculosis in reference units, in scenarios with ...
Avaliação do desempenho dos serviços de atenção primária à saúde no controle da...
Rabelo,Juliana Veiga Costa; Navarro,Pedro Daibert de; Carvalho,Wânia da Silva; Almeida,Isabela Neves de; Oliveira,Camila Stefânie FonsecaResumo: A Organização Mundial da Saúde destaca a importância da organização e do desempenho dos serviços de saúde nas ações de controle da tuberculose. O objetivo deste estudo foi avaliar o desempenho dos serviços de atenção primaria à saúde em Belo Horizonte, Minas Gerais, Brasil, em relação às ações de controle da tuberculose nos eixos Estrutura e Processo, antes e após a utilização do instrumento validado de...
The impact of the stratification by degree of clinical severity and abandonment...
Navarro,Pedro Daibert de; Haddad,João Paulo Amaral; Rabelo,Juliana Veiga Costa; Silva,Claudia Hermínia de Lima e; Almeida,Isabela Neves deABSTRACT Objective: Evaluate the impact of the instrument of the “Stratification by Degree of Clinical Severity and Abandonment Risk of Tuberculosis Treatment” (SRTB) on the tuberculosis outcome. Methods: This study was a pragmatic clinical trial involving patients with a confirmed diagnosis of tuberculosis treated at one of the 152 primary health care units in the city of Belo Horizonte, Brazil, between May of...
Genotype®MTBDRplus and Xpert®MTB/RIF in the diagnosis of tuberculosis and resis...
Soares,Valéria Martins; Almeida,Isabela Neves de; Vater,Maria Cláudia; Alves,Suely; Figueredo,Lida Jouca de Assis; Scherer,LucieneAbstract INTRODUCTION: The present study sought to assess the mean and activity based cost (ABC) of the laboratory diagnosis for tuberculosis through the application of conventional and molecular techniques-Xpert®MTB/RIF and Genotype®MTBDRplus-in a tertiary referral hospital in Brazil. METHODS: The mean cost and ABC formed the basis for the cost analysis of the TB laboratory diagnosis. RESULTS: The mean cost an...
Cost analysis of smear microscopy and the Xpert assay for tuberculosis diagnosi...
Figueredo,Lida Jouca de Assis; Miranda,Silvana Spíndola de; Santos,Lucas Benício dos; Manso,Caroline Gontijo Gonçalves; Soares,Valéria MartinsAbstract INTRODUCTION: Rapid and accurate tuberculosis detection is critical for improving patient diagnosis and decreasing tuberculosis transmission. Molecular assays can significantly increase laboratory costs; therefore, the average time and economic impact should be evaluated before implementing a new technology. The aim of this study was to evaluate the cost and average turnaround time of smear microscopy ...
Detection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE N...
Miranda,Silvana Spindola de; Almeida,Isabela Neves de; Mansur,Maria de Fátima Filardi Oliveira; Figueredo,Lida Jouca de Assis; Carvalho,Wânia da SilvaAbstract (1) Background: The Commercial Kit SIRE Nitratase® PlastLabor, is a drug susceptibility test kit used to detect Mycobacterium tuberculosis resistance to first-line TB treatment drugs. The present study aimed at evaluating its performance in a multicenter study. (2) Methods: To determine its accuracy, the proportion methods in Lowenstein Jensen medium or the BACTECTMMGITTM960 system was used as a gold s...
Factors associated with tuberculosis and multidrug-resistant tuberculosis in pa...
Soares,Valéria Martins; Almeida,Isabela Neves de; Figueredo,Lida Jouca de Assis; Haddad,João Paulo Amaral; Oliveira,Camila Stefanie Fonseca deABSTRACT Objective: To evaluate the risk factors for the development of tuberculosis and multidrug-resistant tuberculosis (MDR-TB) in patients treated at a tertiary referral hospital. Methods: This was a cross-sectional study based on data obtained from patients treated at the Júlia Kubitschek Hospital, located in the city of Belo Horizonte, Brazil, between October of 2012 and October of 2014. We evaluated soci...
Comparative study of RFLP-IS6110 and MIRU-VNTR from Mycobacterium tuberculosis ...
Augusto,Cláudio José; Carvalho,Wânia da Silva; Almeida,Isabela Neves de; Figueiredo,Lida Jouca de Assis; Dantas,Nayanne Gama TeixeiraAbstract DNA genotyping of Mycobacterium tuberculosis has been widely applied in the understanding of disease transmission in many countries. The purpose of this study was to genotype the strains of M. tuberculosis isolated in patients with new tuberculosis (TB) cases in Minas Gerais, as well as to compare the similarity, discriminatory power, and agreement of the clusters between the IS6110 Restriction Fragmen...
Prevalence of latent Mycobacterium tuberculosis infection in prisoners
Navarro,Pedro Daibert de; Almeida,Isabela Neves de; Kritski,Afrânio Lineu; Ceccato,Maria das Graças; Maciel,Mônica Maria DelgadoABSTRACT Objective: To determine the prevalence of and the factors associated with latent Mycobacterium tuberculosis infection (LTBI) in prisoners in the state of Minas Gerais, Brazil. Methods: This was a cross-sectional cohort study conducted in two prisons in Minas Gerais. Tuberculin skin tests were performed in the individuals who agreed to participate in the study. Results: A total of 1,120 individuals were...