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Avaliação das alterações hematológicas no tratamento da leucemia mielóide crôni...
Mesquita, Iran Davi Sena de; Almeida Filho, Tarcísio Paulo de; Moreira-Nunes, Caroline Aquino; Quixada, Acy Telles de Souza; Duarte, Fernando BarrosoA Leucemia Mielóide Crônica (LMC) é uma doença mieloproliferativa clonal caracterizada molecularmente pela formação da fusão gênica BCR-ABL. O mesilato de imatinib (MI), é o tratamento padrão da doença e foi o primeiro inibidor de tirosina-quinase a agir especificamente na oncoproteína BCR-ABL. No entanto, alguns casos de resistência a esta droga têm sido observados, o que faz necessário o uso de drogas mais po...
Avaliação do risco de desenvolver diabetes mellitus tipo 2 em estudantes do cur...
Figueiredo, Monalisa Feliciano; Maia Filho, Pedro Aurio; Almeida Filho, Tarcísio Paulo de; Laurentino, Marília Rocha; Barbosa, Maritza CavalcanteO Diabetes mellitus (DM) é uma doença metabólica de etiologia múltipla, caracterizada por uma hiperglicemia decorrente de uma alteração na secreção ou ação da insulina. O DM tipo 1 (DM1) está relacionado com a deficiência de insulina resultante da destruição das células-β do pâncreas; o DM tipo 2 (DM2) resulta de um processo fisiopatológico que culmina com a resistência à insulina, sendo o DM2 considerado um pr...
Diferenças clínicas entre gêmeas idênticas com anemia falciforme
Laurentino, Marilia Rocha; Almeida Filho, Tarcísio Paulo de; Maia Filho, Pedro A.; Nascimento, Francisco O. F.; Advincula, Adlene F.Sickle cell anemia (SCA) is a genetic disease that causes important clinical manifestations due to chronic hemolysis and vascular occlusion. The aim of this study was to report a rare case of monozygotic twins diagnosed with SCA, presenting a different clinical characteristic. An interview with the patients was carried out and the medical records were consulted. One patient has a history of malleolar ulcer in t...
Double-blind clinical trial of arginine supplementation in the treatment of adu...
Eleutério, Renata Mirian Nunes; Nascimento, Francisco O.; Araújo, Tamara G.; Castro, Marilena F.; Almeida Filho, Tarcísio Paulo de; Maia Filho, Pedro A.Background. Sickle cell anaemia (SCA) is the most prevalentmonogenic disease in Brazil. In SCA, haemoglobin S (HbS) is formed, whichmodifies red blood cell morphology. Intravascular haemolysis occurs, in which free Hb and free radicals degrade nitric oxide (NO) and release arginase, which reduces arginine levels. Because arginine is a substrate for NO formation, this decrease leads to reduced NO (vasodilator) s...
Levothyroxine Replacement Improves Oxidative Status in Primary Hypothyroidism
Masullo, Laís Farias; Magalhães, Rejane Araújo; Lemes, Romélia Pinheiro Gonçalves; Almeida Filho, Tarcísio Paulo de; Castro, Marilena Facundo deObjective: Although hypothyroidism has been linked to oxidative stress, data regarding the relationship between thyroid hormone levels and oxidative stress is still inconsistent. This study was designed to evaluate the effect of levothyroxine replacement on oxidative stress in women with primary hypothyroidism. Design: A total of 25 female patients with primary hypothyroidism were included. Oxidative stress mar...
Association of oxidative stress and DNA damage with grafting time in patients w...
Santos, Thayna Nogueira dos; Duarte, Fernando Barroso; Maia Filho, Pedro Aurio; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteSANTOS, Thayna Nogueira .; The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage i...
Expressão e perfil mutacional do gene BCR-ABL em pacientes com leucemia mieloid...
Almeida Filho, Tarcísio Paulo deMost patients with chronic myeloid leukemia (CML) express the transcripts b2a2, b3a2 or both of the BCR-ABL gene. The role of these transcripts in the prognosis of patients undergoing treatment with tyrosine kinase inhibitors (ITKs) has been poorly investigated and remains unclear to date. In this study, we evaluated the prognostic value of the main transcripts in patients with CML, by evaluating the expression...
Pancytopenia during tyrosine kinase inhibitor treatment–coexistence of chronic ...
Quixada, Acy; Maia Filho, Pedro Aurio; Almeida Filho, Tarcísio Paulo de; Duarte, Fernando Barroso; Moreira-Nunes, Caroline AquinoBackground: Visceral leishmaniasis is a zoonosis characterized by chronic evolution of symptoms; it usually appears 2 to 4 months after the initial infection, with multiple cutaneous lesions and systemic involvement, which if left untreated results in death in 90 % of cases. Case presentation: We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed s...