3 documents found, page 1 of 1
Bacteriocin dynamics in Enterococcus faecium and Enterococcus lactis: implicati...
Almeida-Santos, Ana C.; Tedim, Ana P.; Duarte, Bárbara; Brilhante, Michael; Coque, Teresa M.; Novais, Carla; Freitas, Ana R.; Peixe, LuísaBackground: Enterococcus faecium-Efm and E.lactis-Elts (former Efm-cladeB) colonize the human gut, with Efm also being a leading hospital-pathogen. Dynamics influencing strain dominance in competitive environments (e.g., infection/colonization) are not fully understood, but bacteriocins may provide competitive advantage to clinical Efm or commensal Elts strains. Objective: We explored bacteriocin content of con...
A challenge in antibiotic stewardship: detection of vancomycin-variable Enteroc...
Almeida-Santos, Ana C.; Tedim, Ana P.; Duarte, Bárbara; Silva, Luís M.; Teixeira, Júlio; Castro, Ana P.; Novais, Carla; Peixe, Luísa; Freitas, Ana R.Background: Vancomycin-variable-enterococci (VVE) are vanA+ enterococci expressing a vancomycin-susceptible phenotype that can revert to a resistant phenotype (VRE) after vancomycin exposure. Objective: We aimed to screen and characterize VVE in a large collection of Enterococcus faecium (Efm) [1]. Methods: We performed a vanA-PCR screening on an extensive Efm collection (2009-2022), including hospital (n=255) ...
Characterization of vancomycin-resistant Enterococcus faecium causing infection...
Antunes, Beatriz; Almeida-Santos, Ana C.; Read, Antónia; Alves, Valquíria; Novais, Carla; Peixe, Luísa; Freitas, Ana R.Background: Vancomycin-resistant Enterococcus faecium (VREfm) are leading nosocomial pathogens linked to high mortality rates and costs [1,2]. VREfm are also included in the WHO global priority list of antibiotic-resistant bacteria for which new antibiotics are urgently needed [3]. Their epidemiology is puzzling within Europe and VREfm data in Portuguese hospitals are lacking since the 2000s. Objective: We...