ALK gene rearrangements are important oncogenic driver alterations in non-small-cell lung cancer and a predictive factor. When present, it enables the use of tyrosine kinase inhibitors, such as Alectinib. This drug can lead to anemia and erythrocyte morphological changes. We present the case of a 72-year-old patient diagnosed with stage IV non-small cell lung cancer treated with Alectinib in the first line. The...
A fibrous histiocytoma is a benign tumoral lesion generally localized in the dermis or the superficial subcutaneous tissue. Fibrous histiocytoma of the lung is a very rare tumor, with only a few cases in the literature. We present a case of a 48-year-old man, asymptomatic, with a solitary pulmonary nodule with a high metabolism in PET/TC. Given the location and suspicious hypermetabolism in PET/TC, the patient ...
Advanced-stage thymoma may present, in rare cases, with extensive pleural disease at the time of diagnosis (Masaoka IVA). Accounting for the low incidence and the variety of therapeutic strategies available in the literature, no consensual treatment has been established. A multimodal treatment plan including surgery, radiotherapy and chemotherapy should be preferred, allowing for a more favorable prognosis. Com...
Introduction: Lung cancer (LC) is one of the most frequent oncological diseases in the world, and the use of immunotherapy is a substantial progress regarding new therapeutic options. Fatigue is the most frequently reported adverse effect in patients starting immunotherapy treatment, but it remains underdiagnosed. The purpose of this study was to identify whether the assessment of fatigue, recorded by the clini...