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Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treat...

Rodrigues-Santos, Paulo; López-Sejas, Nelson; Almeida, Jani-Sofia; Ruzičková, Lenka; Couceiro, Patrícia; Alves, Vera; Campos, Carmen; Alonso, Corona

Natural killer (NK) cells are a very important component of the innate immune response involved in the lysis of virus infected and tumor cells. Aging has a profound impact in the frequency, phenotype and function of NK cells. Chronic Myeloid Leukemia (CML) is caused by the BCR-ABL gene formation encoding aberrant oncoprotein tyrosine kinase. Treatment with tyrosine kinase inhibitors (TKIs) induces durable deep ...

Date: 2018   |   Origin: Estudo Geral - Universidade de Coimbra
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