2 documents found, page 1 of 1
Tuning the stiffness of surfaces by assembling genetically engineered polypepti...
Costa, R. R.; González-Pérez, M.; Herrero-Gutiérrez, M.; Pires, R. A.; Alonso, M.; Rodríguez-Cabello, J. C.; Reis, R. L.; Pashkuleva, I.We introduce elastin-like recombinamers (ELRs) as polypeptides with precise amino acid positioning to generate polypeptide coatings with tunable rigidity. Two ELRs are used: V84-ELR, a hydrophobic monoblock, and EI-ELR, an amphiphilic diblock. Both were modified with the amine-reactive tetrakis (hydroxymethyl) phosphonium chloride compound. We evaluated the affinity, the conformation, and the dissipative behavi...
Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein-pepti...
Inostroza-Brito, K. E.; Collin, E.; Siton-Mendelson, O.; Smith, K. H.; Monge-Marcet, A.; Ferreira, D. S.; Rodríguez, R. P.; Alonso, M.Controlling molecular interactions between bioinspired molecules can enable the development of new materials with higher complexity and innovative properties. Here we report on a dynamic system that emerges from the conformational modification of an elastin-like protein by peptide amphiphiles and with the capacity to access, and be maintained in, non-equilibrium for substantial periods of time. The system enabl...