2 documents found, page 1 of 1
Spontaneous co-assembly of molecularly designed building blocks into hierarchic...
Smith, K. H.; Inostroza, K. E.; Alonso, Matilde; Reis, R. L.; Azevedo, Helena S.; Mata, A.A major limitation in generating materials using bottom-up strategies is the lack of order at the macroscale. In this work, we show that two self-assembling molecules, an elastin-like polymer (ELP) and a peptide amphiphile (PA), can interact to spontaneously to form hierarchically ordered, dynamic, bioactive, macrotubes. An RGD-containing ELP and a PA (C16V3A3K3) were synthesised using standard methods. The add...
Development of an injectable system based on elastin-like recombinamer particle...
Oliveira, Mariana B.; Song, Wenlong; Martín, Laura; Oliveira, Sara M.; Caridade, S. G.; Alonso, Matilde; Rodríguez-Cabello, José Carlos; Mano, J. F.An elastin-like recombinamer (ELR) containing the RGD cell adhesion domain was used to fabricate microparticles by an innovative and affordable process based on the use of superhydrophobic surfaces. Two microparticles types with different crosslinking extents were prepared. The biological response was tested using an osteoblast-like cell line (SaOs-2) performing proliferation and alkaline phosphatase (ALP) quan...