22 documents found, page 1 of 3

Viral genetics and transmission dynamics in the second wave of mpox outbreak in...

Epidemiological and clinical aspects of Cutaneous and Mucosal Leishmaniases in ...

Leishmania infantum, a zoonotic vector-born parasite, is endemic in the Mediterranean region, presenting mostly as visceral (VL), but also as cutaneous (CL) and mucosal leishmaniasis (ML). This study aimed to describe the epidemiological and clinical aspects of the CL and ML cases diagnosed in mainland Portugal between 2010 and 2020. Collaboration was requested from every hospital of the Portuguese National Hea...

Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in...

Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the hi...

Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in...

Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the hi...

Photosensitization of human skin fibroblasts by vemurafenib promotes pleiotropi...

Vemurafenib (VB), a BRAF inhibitor and a first-line treatment for unresectable or metastatic melanoma, is strongly phototoxic towards normal skin cells. Herein, we show that in cultured HS 68 human diploid dermal fibroblasts, low concentrations of VB suffice to promote photosensitization to low doses of UVA (∼ 5 J/cm2), as evidenced by a significant decrease in cell viability. In contrast to data obtained in ch...

The clinical spectrum of response to narrowband‐UVB therapy in chronic plaque p...

Psoriasis is a common chronic inflammatory disorder with serious quality of life impairment. Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI) are the most validated scores for accessing psoriasis severity and response to therapy. Plaque psoriasis is the most common form of the disease. In 20% of patients, it is moderate to severe and dictates the need for alternative therapeutic op...

Human immunodeficiency virus infection may be a contributing factor to monkeypo...

To the Editor: An outbreak of monkeypox has emerged, and more than 13,000 cases have already been confirmed worldwide. In our department, we have 42 confirmed cases so far. All of them are cisgender males presenting with lesions in the genital, perianal, or perioral areas (Fig 1). Interestingly, we observe a disproportionate number of individuals living with the human immunodeficiency virus (HIV). Below, we pre...

Monkeypox virus infection in HIV1‐coinfected patients previously vaccinated aga...

Monkeypox is a zoonotic orthopoxvirus that incidentally causes disease in humans similar to smallpox, although with lower mortality. This virus is endemic to western and central Africa, with outbreaks in occidental countries related to exotic pet trade and international travel. Coincident immunity to monkeypox virus was previously achieved with vaccinia virus vaccination; however, eradicating smallpox and subse...

Allergic contact dermatitis caused by elastic bands of an N95 mask

A 29-year-old woman, Fitzpatrick phototype II, with a personal history of atopy, presented with face and neck dermatitis lasting 6 months. During the past year, she worked as a nurse in a coronavirus disease 2019 (COVID-19)–dedicated ward of a tertiary hospital. The dermatitis had developed since she started wearing N95 masks. She referred to using two N95 masks, with similar symptoms: 3M Aura 9320+ N95 mask (3...

Is there a link between guttate psoriasis and SARS-CoV-2? A series of three cases

Guttate psoriasis (GP) is an acute form of psoriasis that is associated with bacterial infections, mainly streptococcal, which cause superantigen-induced immune activation. Viral upper respiratory infections may also be implicated, typically occurring two to three weeks before the onset of guttate lesions. We report three cases of GP following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infecti...