10 documents found, page 1 of 1
Disclosing the antitumour potential of the marine bromoditerpene sphaerococceno...
Alves, Celso; Silva, Joana; Afonso, Marta B.; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Pinteus, Susete; Gaspar, Helena; Goettert, Marcia I.Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1–100 μM; 24 h) were accomplished in eight different tumour cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-SY5Y, SK-MEL-28). Deeper studies were conducted on MFC-7 cells, nam...
Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated...
Alves, Celso; Silva, Joana; Pinteus, Susete; Alonso, Eva; Alvariño, Rebeca; Duarte, Adriana; Marmitt, Diorge; Goettert, Márcia Inês; Gaspar, HelenaMarine natural products have exhibited uncommon chemical structures with relevant antitumor properties highlighting their potential to inspire the development of new anticancer agents. The goal of this work was to study the antitumor activities of the brominated diterpene sphaerodactylomelol, a rare example of the dactylomelane family. Cytotoxicity (10-100 µM; 24 h) was evaluated on tumor cells (A549, CACO-2, H...
Cytotoxic mechanism of sphaerodactylomelol, an uncommon bromoditerpene isolated...
Alves, Celso; Silva, Joana; Pinteus, Susete; Alonso, Eva; Alvarino, Rebeca; Duarte, Adriana; Marmitt, Diorge; Geottert, Márcia Inês; Gaspar, HelenaMarine natural products have exhibited uncommon chemical structures with relevant antitumor properties highlighting their potential to inspire the development of new anticancer agents. The goal of this work was to study the antitumor activities of the brominated diterpene sphaerodactylomelol, a rare example of the dactylomelane family. Cytotoxicity (10–100 M; 24 h) was evaluated on tumor cells (A549, CACO-2, HC...
Sphaerococcus coronopifolius bromoterpenes as potential cancer stem cell-target...
Alves, Celso H.; Serrano, Eurico; Silva, Joana; Rodrigues, Carlos; Pinteus, Susete; Gaspar, Helena; Botana, Luis M.; Alpoim, Maria C.; Pedrosa, RuiCancer is one of the major threats to human health and, due to distinct factors, it is expected that its incidence will increase in the next decades leading to an urgent need of new anticancer drugs development. Ongoing experimental and clinical observations propose that cancer cells with stem-like properties (CSCs) are involved on the development of lung cancer chemoresistance. As tumour growth and metastasis ...
Sphaerococcus coronopifolius bromoterpenes as potential cancer stem cell-target...
Alves, Celso; Serrano, Eurico; Silva, Joana; Rodrigues, Carlos; Pinteus, Susete; Gaspar, Helena; Botana, Luis M.; Alpoim, Maria C.; Pedrosa, RuiCancer is one of the major threats to human health and, due to distinct factors, it is expected that its incidence will increase in the next decades leading to an urgent need of new anticancer drugs development. Ongoing experimental and clinical observations propose that cancer cells with stem-like properties (CSCs) are involved on the development of lung cancer chemoresistance. As tumour growth and metastasis ...
Sphaerococcus coronopifolius bromoterpenes as potential cancer stem celltargeti...
Alves, Celso; Serrano, Eurico; Silva, Joana; Rodrigues, Carlos; Pinteus, Susete; Gaspar, Helena; Botana, Luís M.; Alpoim, Maria C.; Pedrosa, RuiCancer is one of the major threats to human health and, due to distinct factors, it is expected that its incidence will increase in the next decades leading to an urgent need of new anticancer drugs development. Ongoing experimental and clinical observations propose that cancer cells with stem-like properties (CSCs) are involved on the development of lung cancer chemoresistance. As tumour growth and metastasis ...
From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Der...
Alves, C. Henrique; Silva, Joana; Pinteus, Susete; Gaspar, Helena; Alpoim, Maria C.; Botana, Luis M.; Pedrosa, RuiMarine environment has demonstrated to be an interesting source of compounds with uncommon and unique chemical features on which the molecular modeling and chemical synthesis of new drugs can be based with greater efficacy and specificity for the therapeutics. Cancer is a growing public health threat, and despite the advances in biomedical research and technology, there is an urgent need for the development of ...
From marine origin to therapeutics: the antitumor potential of marine algae-der...
Alves, Celso; Silva, Joana; Pinteus, Susete; Gaspar, Helena; Alpoim, Maria C.; Botana, Luís M.; Pedrosa, RuiMarine environment has demonstrated to be an interesting source of compounds with uncommon and unique chemical features on which themolecularmodeling and chemical synthesis of new drugs can be based with greater efficacy and specificity for the therapeutics. Cancer is a growing public health threat, and despite the advances in biomedical research and technology, there is an urgent need for the development of ne...
Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxid...
Fernandes, Maria A. S.; Geraldes, Carlos F. G. C.; Oliveira, Catarina R.; Alpoim, Maria C.The effects of NADH and H2O2 on chromate-induced human erythrocyte hemoglobin oxidation and peroxidation were studied. It was observed that NADH decreases the levels of chromate-induced human erythrocyte hemoglobin oxidation and peroxidation. H2O2 decreases the levels of chromate-induced hemoglobin oxidation, but increases the levels of chromate-induced peroxidation. The ability of H2O2 to decrease the levels o...
Chromate-induced human erythrocytes haemoglobin oxidation and peroxidation: inf...
Fernandes, Maria A. S.; Geraldes, Carlos F. G. C.; Oliveira, Catarina R.; Alpoim, Maria C.In order to attenuate or to prevent chromate-induced human erythrocytes injury, the influence of vitamin E, vitamin C, salicylate, deferoxamine, and N-ethylmaleimide on chromate-induced human erythrocytes haemoglobin oxidation and peroxidation were investigated. It was observed that pretreatment of human erythrocytes with vitamin E (20 [mu]M), vitamin C (1 mM), salicylate (3 mM), and deferoxamine (4 mM) signifi...