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Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor ...

Valli,Marilia; Altei,Wanessa; Santos,Ricardo N. dos; Lucca Jr.,Emilio C. de; Dessoy,Marco A.; Pioli,Renan M.; Cotinguiba,Fernando; Cachet,Xavier

Piperlongumine is a natural amide alkaloid isolated from several species of Piper and is described in the literature as selectively cytotoxic to several cancer cell lines. Inhibiting cell migration has gained considerable interest as an approach for discovering antimetastatic agents because this process is fundamental to metastasis. Piperlongumine, selected from cell-based assay screening of NuBBE Database, inh...

Date: 2017   |   Origin: Oasisbr
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