11 documents found, page 1 of 2
A first-in-class inhibitor of homologous recombination DNA repair counteracts t...
Calheiros, Juliana; Silva, Rita; Barbosa, Filipa; Morais, João; Moura, Sara Reis; Almeida, Sofia; Fiorini, Elena; Mulhovo, Silva; Aguiar, Tatiana QuintaThe online version contains supplementary material available at: https://doi.org/10.1038/s41467-022-32178-3; Background Pancreatic ductal adenocarcinoma (PDAC) is among the cancer types with poorest prognosis and survival rates primarily due to resistance to standard-of-care therapies, including gemcitabine (GEM) and olaparib. Particularly, wild-type (wt)BRCA tumours, the most prevalent in PDAC, are more resist...
Evaluation on a supersaturatable self-microemulsifying (s-smdds) formulation of...
JIANG,Qingwei; WANG,Tao; LI,GaoAbstract To enhance the dissolution and oral bioavailability of poorly water-soluble biphenyl dimethyl dicarboxylate (BDD), the supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) was developed by adding a water-soluble polymer PVP to prevent precipitation of the drug and maintain a supersaturate state in vivo. Ternary phase diagrams were drawn to evaluate the microemulsification domain. The ...
Three-N-butyphthalide alleviates early brain injury caused via subarachnoid hem...
ZHANG,XinNa; GUO,DongMei; ZHANG,Xin; ZHANG,WenHui; WANG,Tao; ZHANG,LeiAbstract The influences of 3-N-butyphthalide (NBP) on early brain injury (EBI) induced via mild subarachnoid hemorrhage (SAH) and its mechanism were explored. Establishment of SAH model was via autologous blood injection. The protection of NBP on EBI in SAH model mice was evaluated. Determination of neuronal apoptosis was conducted. Detection of blood brain barrier (BBB), ZO-1, claudin-5, occludin and MMP-9 was...
Plasma miR-1273g-3p acts as a potential biomarker for early Breast Ductal Cance...
Guo,Huan; Zeng,Xiangting; Li,Haining; Guo,Yanxiang; Wang,Tao; Guo,Hongyun; Zhu,Gongjian; Wang,Lan; Zhou,Haihong; Liu,Kedan; Chen,Xiaoyi; Wang,HaitaoAbstract Circulating miRNAs presenting in plasma in a stable manner have been demonstrated their potential role as a promising biomarkers in many human diseases, such as Alzheimer’s disease, melanoma and ovarian carcinoma. However, few circulating miRNAs could be used for breast ductal cancer diagnosis. Here, we identified miR-1273g-3p as a biomarker for detecting breast ductal cancer. We detected miR-1273g-3p ...
Molecular diversity in a germplasm collection of avocado accessions from the tr...
Ge,Yu; Hu,Fuchu; Tan,Lin; Wu,Bin; Wang,Tao; Zhang,Teng; Ma,Funing; Cao,Jianqiu; Xu,Zhining; Zhan,RulinAbstract Avocado is an economically important crop and widely cultivated in the tropical and subtropical regions of China, whereas little is known about its genetic diversification. Twenty-six EST-SSR markers were developed based on avocado EST sequences. Molecular characterization was applied to assess the genetic relationships among different accessions. In total, nine gSSRs and nine EST-SSRs were selected to...
Investigation on Friction and Wear Properties of High-Temperature Bearing Steel...
He,Qiang; Li,Anling; Qu,Wenhong; Zhang,Yong; Wang,Tao; Kong,LinghaoThis paper presented a study of friction and wear on 9Cr18Mo when rubbed against other materials (steel-304, steel-440C, steel-GCr15 or silicon nitride ceramic ball) at high temperature conditions. Friction and wear tests were carried out with universal a friction and wear testing machine. The wear morphology was analyzed by a Nanovea three-dimensional profilometer and trinocular positive Gang metallurgical mic...
Retroperitoneoscopic resection of retroperitoneal nonadrenal ganglioneuromas: o...
Shi,Changjin; Li,Feng; Wang,Yanchao; Pei,Long; Wang,TaoABSTRACT Objective: To report our experience of retroperitoneoscopic technique in semi-lateral decubitus position for the retroperitoneal nonadrenal ganglioneuromas in 18 patients, and to evaluate its clinical outcomes. Materials and Methods: From January 2012 to May 2016, 18 patients with retroperitoneal nonadrenal ganglioneuromas underwent retroperitoneoscopic resection. With the patients in semi-lateral decu...
Prediction of overall survival for patients with metastatic castration-resistan...
Guinney, Justin; Wang, Tao; Laajala, Teemu D.; Winner, Kimberly Kanigel; Bare, J. Christopher; Neto, Elias Chaibub; Khan, Suleiman A.; Peddinti, GopalBackground: Improvements to prognostic models in metastatic castration-resistant prostate cancer have the potential to augment clinical trial design and guide treatment strategies. In partnership with Project Data Sphere, a not-for-profit initiative allowing data from cancer clinical trials to be shared broadly with researchers, we designed an open-data, crowdsourced, DREAM (Dialogue for Reverse Engineering Ass...
Remote limb ischemic post-conditioning attenuates ischemia-reperfusion injury i...
Zhang,Yi; Xu,Hua; Wang,Tao; He,Jinguang; Wei,Jiao; Wang,Tingliang; Dong,JiashengPURPOSE: To investigate the effect of remote ischemic post-conditioning (RIPoC) against ischemia-reperfusion (I/R) injury on flaps of rats. METHODS: Sprague-Dawley rats were randomized into the Sham, Control, RIPoC1 and RIPoC2 groups. All the animals were submitted to a 5×4 cm superficial inferior epigastric artery flap. Eight hours of flap ischemia was induced and two protocols of limb RIPoC were applied. Tiss...
Small activating RNA induces myogenic differentiation of rat adipose-derived st...
Wang,Chenghe; Chen,Zhong; Wu,Jia; Zhang,Yan; Hu,Jia; Ge,Qiangqiang; Wang,Tao; Yang,Weimin; Xu,Hua; Liu,Jihong; Ye,ZhangqunABSTRACTPurpose:RNA activation (RNAa) is a mechanism of gene activation triggered by promoter-targeted small double stranded RNAs (dsRNAs), also known as small activating RNAs (saRNAs). Myogenic regulatory factor MyoD is regarded as the master activator of myogenic differentiation cascade by binding to enhancer of muscle specific genes. Stress urinary incontinence (SUI) is a condition primarily resulted from ur...