16 documents found, page 1 of 2

Nanostructured lipid carriers loaded with cannabidiol: A novel antibiofilm appr...

Introduction: Staphylococcus aureus and Staphylococcus epidermidis are major contributors to skin dysbiosis and infections, e.g. folliculitis and intravascular catheter infections, forming biofilms that enhance their resistance to antibiotics and immune responses. Given that antibiotic resistance is a serious challenge, new solutions are constantly being explored. The endocannabinoid system is essential for mai...

Nanostructured lipid carriers enriched hydrogels for skin topical administratio...

Chronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing skin damage and aging. Because of their well-known skincare and protective benefits, quercetin (Q) and omega-3 fatty acids (ω3) have attracted the attention of the dermocosmetic and pharmaceutical sectors. However, both bioactives have inherent properties that lim...

Riluzole-loaded lipid nanoparticles for brain delivery: preparation, optimizati...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, with a median survival of only 2 to 4 years. Riluzole, a drug commonly used in the management of ALS, has a low aqueous solubility and limited bioavailability. ALS treatment is also hindered by the presence of the blood–brain barrier (BBB) that preserves the delicate homeostasis of the cerebral milieu, isolating it and making brain drug d...

Nanostructured lipid carriers enriched hydrogels for skin topical administratio...

Chronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing skin damage and aging. Because of their well-known skincare and protective benefits, quercetin (Q) and omega-3 fatty acids (ω3) have attracted the attention of the dermocosmetic and pharmaceutical sectors. However, both bioactives have inherent properties that lim...

Editorial on special issue “Lipid nanosystems for local drug delivery”

Formulation, characterization, and cytotoxicity evaluation of lactoferrin funct...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood–brain barrier (BBB), which restricts the access of drugs commonly used in ALS, such as riluzole, to the brain. To overcome these limitations and increase brain targeting, riluzole-loaded nanostructured lipid carriers (NL...

Personalised esomeprazole and ondansetron 3D printing formulations in Hospital ...

Individualised medicine demands the formulation of pharmacotherapy in accordance with the characteristics of each patient’s health condition, and paediatrics is one of the areas that needs this approach. The 3D printing of oral doses is one method for achieving customised medicine in paediatrics. In this work, pre-formulation studies were conducted to evaluate the viability of using specific raw materials to pr...

Challenges in nanomaterials characterization - from definition to analysis (cap...

Nanomaterials have outstanding properties and have several applications, ranging from foods, cosmetics, pharmaceuticals to energy, construction, etc. As with all novel products, the benefits of nanomaterials use must be weighed against its health and environmental impact. They have different origins, natural, incidental, or engineered, they are widespread, and they need to be classified and characterized for va...

Formulation, Characterization, and Cytotoxicity Evaluation of Lactoferrin Funct...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood–brain barrier (BBB), which restricts the access of drugs commonly used in ALS, such as riluzole, to the brain. To overcome these limitations and increase brain targeting, riluzole-loaded nanostructured lipid carriers (NL...

Omega-3- and resveratrol-loaded lipid nanosystems for potential use as topical ...

Resveratrol (RSV) and omega 3 (!3), because of their biological favorable properties, have become subjects of interest for researchers in dermocosmetic and pharmaceutical industries; however, these bioactives present technological limitations that hinder their effective delivery to the target skin layer. To overcome the stability and skin permeation limitations of free bioactives, this work proposes a combined ...