6 documents found, page 1 of 1
The Transition From Undernutrition to Overnutrition Under Adverse Environments ...
Leocádio, Paola Caroline L.; Lopes, Synara C.; Dias, Ronaldo P.; Alvarez-Leite, Jacqueline I.; Guerrant, Richard L.; Malva, João O.; Oriá, Reinaldo B.Nutritional transition is an important public health issue in developing countries, where switch from undernutrition to overnutrition/obesity is rapidly occurring, often within two or three generations. Such transition is related to changes in lifestyle, with people having more access to western high-caloric diets. In developing countries, settings of poverty, poor sanitation and hygiene are still common, where...
Obesity: more than an inflammatory, an infectious disease?
Leocádio, Paola C. L.; Oriá, Reinaldo B.; Crespo-Lopez, Maria Elena; Alvarez-Leite, Jacqueline I.Much is discussed if obesity or diet components modify the “healthy” microbiota or if microbiota modifications trigger events that culminate in obesity. This association is probably reciprocal, and inflammation has crucial participation on it. We will discuss recent studies showing gut microbiome as an obesogenic factor and the mechanisms linked to the associated of diet, microbiota, and low-grade inflammation.
Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neur...
Pinto, Daniel V.; Raposo, Ramon S.; Matos, Gabriella A.; Alvarez-Leite, Jacqueline I.; Malva, João O.; Oriá, Reinaldo B.Mercury (Hg) is a well-recognized biohazard for the nervous system. Methylmercury (MeHg) is an organic methylated form of Hg, highly toxic to humans, targeting the brain, as MeHg is rapidly absorbed, and easily reaches and crosses the blood-brain barrier (Takahashi et al., 2017). Neurological symptoms may vary from acute motor and visual effects to marked behavioral and psychiatric alterations. At higher neurot...
In the heart of the Amazon: noncommunicable diseases and apolipoprotein E4 geno...
Arrifano, Gabriela P. F.; Alvarez-Leite, Jacqueline I.; Souza-Monteiro, José Rogério; Augusto-Oliveira, Marcus; Paraense, Ricardo; Macchi, Barbarella M.The Amazon River basin is the largest tropical forest in the world. Most of the Amazon belongs to Brazil, a developing country that currently faces huge challenges related to the consolidation of its universal healthcare system. Noncommunicable diseases (NCDs) are the leading cause of death in Brazil, accounting for 74% of all deaths, and NCDs are probably underestimated in Amazonian population because of their...
Genetic susceptibility to neurodegeneration in Amazon: apolipoprotein E genotyp...
Arrifano, Gabriela P. F.; Martín-Doimeadios, Rosa C. R.; Jiménez-Moreno, María; Fernández-Trujillo, Sergio; Augusto-Oliveira, MarcusHuman exposure to mercury is a serious problem of public health in Amazon. As in other vulnerable populations throughout the world, Amazonian riverine populations are chronically exposed to this metal and some symptoms of mercury intoxication were already detected in these populations. However, studies on the genetic susceptibility to mercury toxicity in the Amazon are scarce, and they tested a limited number o...
Prolonged maternal separation induces undernutrition and systemic inflammation ...
Figueiredo, Ítalo Leite; Frota, Priscila B.; Cunha, Davi G. da; Raposo, Ramon da Silva; Canuto, Kildere M.; Andrade, Geanne M. de; Sousa, NunoObjective: Prolonged maternal separation (PMS) in the first 2 wk of life has been associated with poor growth with lasting effects in brain structure and function. This study aimed to investigate whether PMS-induced undernutrition could cause systemic inflammation and changes in nutrition-related hormonal levels, affecting hippocampal structure and neurotransmission in C57BL/6J suckling mice. Methods: This stud...